With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.372118-01-9,Methyl 4,6-dichloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.
Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (109 mg, 0.53 mmol),3-fluoro-4- (tetrahydro-2H-pyran-4-yl) aniline 95c (103mg, 0.53mmol),Diisopropylethylamine (682 mg, 5.28 mmol) and acetonitrile (4 mL) were mixed, heated to 90 C and stirred for 18 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 100/0 to 3/7),The target product 6-chloro-4-((3-fluoro-4- (tetrahydro-2H-pyran-4-yl) phenyl) amino) pyridazine-3-carboxylic acid methyl ester 95d (67 mg, orange oily ), Yield: 34%.
372118-01-9, 372118-01-9 Methyl 4,6-dichloropyridazine-3-carboxylate 17848322, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem