With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50901-46-7,1-(Pyridazin-4-yl)ethanone,as a common compound, the synthetic route is as follows.
To a solution of 1-pyridazin-4-ylethanone (0.3 g) in 1 ,4-dioxane (1.5 ml_) was added (0920) tert- butyl /V-aminocarbamate (0.327 g) and the reaction heated at 70C for 90 minutes. The reaction mixture was concentrated to give tert- butyl A/-[(E)-1-pyridazin-4-ylethylideneamino]carbamate which was used without further purification. (0921) NMR (400 MHz, CDCIs) 9.59 (dd, 1 H), 9.19 (dd, 1 H), 8.00 (s, 1 H), 7.77 (dd, 1 H), 2.21 (s, 3H), 1.57 (s, 9H), 50901-46-7
As the paragraph descriping shows that 50901-46-7 is playing an increasingly important role.
Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; SCUTT, James, Nicholas; WILLETTS, Nigel, James; SONAWANE, Ravindra; PHADTE, Mangala; KANDUKURI, Sandeep, Reddy; SASMAL, Swarnendu; ARMSTRONG, Sarah; MCGRANAGHAN, Andrea; (155 pag.)WO2019/185875; (2019); A1;,
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