88497-27-2, 3-Amino-6-bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To ie/f-butyl 3-(4,4 5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1 ]-oct-2-ene-8- carboxylate (1 .93 g, 5.75 mmol) and 6-bromopyridazin-3-amine (1 .00 g, 5.75 mmol) in 1 ,4- dioxane (25 mL) is added 2M aq. Na2C03 solution (11 .5 mL, 23.0 mmol) and Xphos 2nd generation catalyst (136 mg, 0.17 mmol). The reaction mixture is degassed with argon and stirred at 100C for 2 h. All volatiles are evaporated under reduced pressure. The crude material is purified by normal phase chromatography to obtain the title compound. (0913) Yield: 0.80 g (46%) ESI-MS: m/z = 303 (M+H)+, 88497-27-2
The synthetic route of 88497-27-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; BOUYSSOU, Thierry; GOTTSCHLING, Dirk; HEINE, Niklas; SMITH KEENAN, Lana Louise; LOWE, Michael D.; RAZAVI, Hossein; SARKO, Christopher Ronald; SURPRENANT, Simon; TAKAHASHI, Hidenori; TURNER, Michael Robert; WU, Xinyuan; (182 pag.)WO2019/81637; (2019); A1;,
Pyridazine – Wikipedia
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