20744-39-2, Pyridazin-4-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
20744-39-2, To a microwave reaction tube were added 12c (250 mg, 0.273 mmol), pyridazin-4-amine (39.0 mg, 0.410 mmol), DIPEA (0.191 mL, 1.093 mmol), HATU (125 mg, 0.328 mmol) and DMF (15 mL). The mixture was heated to 100 C for 2 hrs under microwave. The mixture was cooled to room temperature and purified by MADP (acidic mobile phase) to give the title compound (30.5 mg, 0.079 mmol, 28.9 % yield) as a yellow solid. LCMS: 375.2 [M+H]+. 1H NMR (400 MHz, DMSO-d6): delta 10.72 (s, 1H), 9.19 (br., 1H), 9.05 (d, J= 5.6 Hz, 1H), 8.01 (d, J= 3.6 Hz, 1H), 7.48 (d, J= 6.8 Hz, 2H), 7.34 (d, J= 6.8 Hz, 3H), 7.19 (d, J= 8.8 Hz, 1H), 6.85 (br., 1H), 6.75 (d, J= 8.8 Hz, 1H), 5.15 (s, 2H), 3.22 (br., 4H), 1.96 (br., 4H). 13C NMR (101 MHz, CDCl3): delta 165.1, 151.5, 147.9, 143.7, 143.6, 137.6, 135.3, 129.6, 129.3, 128.8, 120.7, 117.1, 114.9, 114.1, 114.0, 73.1, 48.1, 25.5. HRMS (ESI): m/z calcd for C22H22N4O2 [M+H]+ 375.1821, found [M+H]+ 375.1816.
As the paragraph descriping shows that 20744-39-2 is playing an increasingly important role.
Reference£º
Article; Ding, Xiao; Stasi, Luigi Piero; Dai, Xuedong; Long, Kai; Peng, Cheng; Zhao, Baowei; Wang, Hailong; Sun, Changhui; Hu, Huan; Wan, Zehong; Jandu, Karamjit S.; Philps, Oliver J.; Chen, Yan; Wang, Lizhen; Liu, Qian; Edge, Colin; Li, Yi; Dong, Kelly; Guan, Xiaoming; Tattersall, F. David; Reith, Alastair D.; Ren, Feng; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 212 – 215;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem