With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7252-84-8,3-Amino-6-methoxypyridazine,as a common compound, the synthetic route is as follows.,7252-84-8
c) 2-ri-(4-fluorophenyl)-3-r2-(4-methoxyphenyl)ethyll-2,5-dioxoimidazolidin- 4-yl1-N-(6-methoxypyridazin-3-yl)acetamide (example 71) TBTU (380.8 mg; 1.16 mmol; 1.5 eq) and DIPEA (270 mu 1-55 mmol; 2 eq) were added to a suspension of 2-[l-(4-fluorophenyl)-3-[2-(4-methoxyphenyl)ethyl]-2,5- dioxoimidazolidin-4-yl] acetic acid (I- 10) (300 mg; 0.78 mmol; 1 eq) in dioxane (4 mL). The reaction mixture was stirred at room temperature for 20 minutes. Then, 6- methoxypyridazin-3-amine (145.9 mg; 1.16 mmol; 1.2 eq) in dimethylformamide (0.2 mL) was added and the reaction mixture was stirred at room temperature for 3 days. The reaction mixture was concentrated to dryness. Saturated ammonium chloride (80 mL) was added and the aqueous layer was extracted with ethyl acetate (3 x 80 mL). The combined organic layers were washed with saturated sodium chloride (3 x 80 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The title compound, 2-[l-(4-fluorophenyl)-3-[2-(4- methoxyphenyl)ethyl]-2,5-dioxoimidazolidin-4-yl]-N-(6-methoxypyridazin-3- yl)acetamide, was obtained in 45% yield (173.8 mg) as a white solid. 1H-NMR (DMSO-d6): delta (ppm) 2.8 (m, 2H), 3.09 (m, 1H), 3.28 (m, 1H), 3.7 (s, 4H), 3.98 (s, 3H), 4.54 (t, 1H, J = 4.1 Hz), 6.84 (d, 2H, J = 8.7 Hz), 7.26 (m, 8H), 8.17 (dt, 1H, J = 9.5 Hz, 1.4Hz), 11.18 (s, 1H); MS (ESI+): m/z = 493.9 [M+H]+ .
The synthetic route of 7252-84-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; VIVALIS; GUEDAT, Philippe; BERECIBAR, Amaya; CIAPETTI, Paola; VENKATA PITHANI, Subhash; TROUCHE, Nathalie; WO2013/171281; (2013); A1;,
Pyridazine – Wikipedia
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