Month: November 2020

An article , which mentions 53896-49-4, molecular formula is C5H3N3. The compound – Pyridazine-3-carbonitrile played an important role in people’s production and life., 53896-49-4

Novel thiosemicarbazones derived from formyl- and acyldiazines: Synthesis, effects on cell proliferation, and synergism with antiviral agents

The synthesis of a series of novel thiosemicarbazones (TSC’s) derived from various alkyl diazinyl (3-pyridazinyl, 4-pyrimidinyl, 2-pyrazinyl) ketones and 3-pyridazinecarbaldehyde and their evaluation against herpes simplex virus (HSV) and human immunodeficiency virus (HIV) as well as the determination of their cytotoxicity are described. In addition, the effects of combination of such TSC’s with the well-known antiviral drugs acyclovir (ACV) and 3′-azido-3′-deoxythymidine (AZT) were studied. Under our experimental conditions, i.e. determination of virus-induced cytopathic effect upon infection of HUT78 cells with HSV-1 and upon infection of MT4 cells with HIV-1, no antiviral activity could be detected with any of the TSC’s. However, pronounced effects on proliferation of these rapidly growing T4 lymphocyte cell lines were observed. Clear structure-activity relationships with regard to these cytotoxic effects could be established: compared to pyridine, pyrazine, or pyrimidine-derived TSC’s most of the 3- pyridazinyl congeners investigated are less cytotoxic: introduction of a methyl group into C-6 of the pyridazine system or prolongation of the acyl moiety in these compounds has essentially no influence; all compounds bearing an N,N-dimethylamino or a cycloamino substituent are much more toxic than those with an NH2 or NHR substituent; the nature of R in the latter type of compounds has only moderate influence. It has been reported that combination of TSC’s with the antiviral agent acyclovir (ACV) results in potentiation of this well-known drug. We evaluated the potential of our series of novel TSC’s in combination with ACV for inhibition of HSV-1-induced cytopathic effect in HUT78 cells and in combination with 3′-azido-3′-deoxythymidine (AZT) for inhibition of HIV-1-induced cytopathic effect in MT4 cells. Only four compounds out of this series, all characterized by an unsubstituted NH2 group, exhibited moderate synergism with the above mentioned antiviral drugs. Our results do not support the previously expressed opinion that TSC’s are selective antiviral agents. In our test systems no evidence for inhibition of virus-induced cytopathic effect was obtained. The TSC derivatives exhibited a broad range of cytotoxic effects, some at concentrations considerably below those reported to have antiviral efficacy. Several of our novel diazine- derived compounds proved advantageous over the previously described pyridine analogues with regard to cytotoxicity. Moderate synergism could be detected for relatively noncytotoxic TSC’s with the antiviral drugs ACV (antiherpes) and AZT (anti-HIV).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N190 – PubChem

 

64068-00-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 64068-00-4, molcular formula is C5H6ClN3, introducing its new discovery.

Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalonates

Compounds useful as schistosomicidal agents are cyclic alkylidenyl N-[6-(R3 R4 N)-4(or 5)-R5 -3-pyridazinyl]aminomethylenemalonates (I), where R3 R4 N is lower-tertiary-amino and R5 is hydrogen or lower-alkyl, are prepared by reacting 3-amino-6-(R3 R4 N)-4(or 5)-R5 -pyridazine (III) with cyclic alkylidenyl alpha-(lower-alkoxymethylene)malonate (IV) or by heating equimolar quantities of III, tri-(lower-alkyl) orthoformate and cyclic alkylidenyl malonate (V). Also shown is cyclic isopropylidenyl N-(6-methylamino-3-pyridazinyl)aminomethylenemalonate, a schistosomicidal agent, and its preparation. Also shown are schistosomicidal compositions comprising as active component a schistosomicidally effective cyclic alkylidenyl N-[6-(R3 R4 N)-4(or 5)-R5 -3-pyridazinyl]aminomethylenemalonate (I) or cyclic isopropylidenyl N-(6-methylamino-3-pyridazinyl)aminomethylenemalonate (II) or salt thereof and a method for the treatment of schistosomiasis which comprises administering to a host infected with schistosomes a schistosomicidally effective amount of said active component.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 64068-00-4, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 64068-00-4

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1046 – PubChem

 

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 19064-67-6, molecular formula is C4H3ClN2O, introducing its new discovery. 19064-67-6

NEW DERIVATIVES OF 6-4{4-[1H-INDOLE-2-SULPHONYL)-PIPERAZIN-1-CARBONYL-PHENYL]}PYRADIZIN-3-ONE

The invention relates to heterocyclic derivatives of formula (I), wherein R2 is amino, a group OR4 or a group-Y-R5 where R4 is hydrogen or C1-4alkyl, Y is C1-4alkylene, R 5 is hydrogen, halo, hydroxy, C1-2alkoxy, C1-2alkoxyC 1-2alkoxyC1-4, or a group NR7R8 where R7 and R8 are independently selected from hydrogen, C1-2alkyl, hydroxyC1-2alkyl or alkoxyC1-2alkyl, or R7 and R8 together with the nitrogen atom to which they are attached form a saturated 5-6-membered heterocyclic ring which optionally contains an additional heteroatom; n is one or two and each R1 is independently selected from halo, haloC1-2alkyl, hydroxy, oxo, amino, C1-2alkylamino or di-C1-2 dialkylamino; or a pharmaceutically acceptable salt thereof. These compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N720 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. 20744-39-2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 20744-39-2, name is Pyridazin-4-amine. In an article£¬Which mentioned a new discovery about 20744-39-2

Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors

A series of novel phenol ether derivatives were designed, synthesized, and evaluated as non-covalent proteasome inhibitors. Most compounds exhibited moderate to excellent proteasome inhibitory activity. In particular, compound 18x proved to be the most potent compound (chymotrypsin-like: IC50 = 49 nM), exhibiting a 2-fold higher potency compared to the reported PI-1840. Besides, compound 18x exhibited excellent metabolic stability and selective anti-proliferative activity against solid cancer cell lines including HepG2 and HGC27, providing incentive for the further development as a potential anticancer agent against solid cancers.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 20744-39-2 is helpful to your research. 20744-39-2

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Pyridazine – Wikipedia,
Pyridazine | C4H4N170 – PubChem

 

1837-55-4, Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter. In a patent£¬patent Assignee is CANDITO, David Annunziato, Which mentioned a new discovery about 1837-55-4, molecular formula is C4H2Cl2N2.

INDAZOLYL-SPIRO[2.2]PENTANE-CARBONITRILE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

The present invention is directed to substituted certain reversed indazolyl-spiro[2.2]pentane-carbonitrile derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson’s Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. 1837-55-4

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1153 – PubChem

 

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 53896-49-4, C5H3N3. A document type is Article, introducing its new discovery., 53896-49-4

Pyridazines. L <1>. Syntheses and Reactions of Phenyl(3-pyridazinyl)methane Derivatives

A convenient approach to phenyl(3-pyridazinyl)ketone (6) and phenyl(3-pyridazinyl)methanol (7) is proposed.Reactions of the related diarylmethyl chloride 8 with various N- and S-nucleophiles were found to afford the expected amines 9a-c, 10a-c and thioethers 11a,b in satisfactory yields.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N194 – PubChem

 

141-30-0, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 141-30-0

Delta 1-pyrrolines used as pesticides

Novel Delta1-pyrrolines of the formula (I) 1in which R1, R2, R3, m and Q have the meanings given in the description, a plurality of processes for preparing these substances and their use for controlling pests.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 141-30-0, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 141-30-0

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1211 – PubChem

 

41933-33-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.41933-33-9, Name is 2-Benzyl-4,5-dichloropyridazin-3(2H)-one, molecular formula is C11H8Cl2N2O. In a Article, authors is Riedl, Zsuzsanna£¬once mentioned of 41933-33-9

Synthesis of new pyridazino[4,5-c]isoquinolinones by Suzuki cross-coupling reaction

Suzuki cross-coupling reaction of 2-alkyl(methyl and benzyl)-5-chloro-4-methoxy- and 2-alkyl(methyl and benzyl)-4-chloro-5-methoxypyridazin-3(2H)-ones with 2-formylphenylboronic acid afforded the corresponding biaryl products which were cyclized with ammonia to yield hitherto undescribed pyridazino[4,5-c]isoquinolinones. Removal of the N-benzyl protective group in position 2 yielded the unsubstituted tricyclic pyridazinones.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 41933-33-9

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3217 – PubChem

 

In an article, published in an article,authors is Bender, Aaron M., once mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine,molecular formula is C4H2Cl2N2, is a conventional compound. this article was the specific content is as follows. 141-30-0

Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists

This letter describes the synthesis and structure activity relationship (SAR) studies of structurally novel M4 antagonists, based on a 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazine core, identified from a high-throughput screening campaign. A multi-dimensional optimization effort enhanced potency at human M4 (hM4 IC50s?141-30-0

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1615 – PubChem

 

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 89089-18-9, molcular formula is C4H2BrClN2, introducing its new discovery. 89089-18-9

SUBSTITUTED PIPERIDINES AS THERAPEUTIC COMPOUNDS

Use of compounds of the general formula (I) and pharmaceutically acceptable salt thereof, in which R, R1 and X have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin Il and/or HIV protease inhibitors.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 89089-18-9, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 89089-18-9

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2836 – PubChem