Month: October 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.,51149-08-7

Method for svnthesising A. If and A. Ig; 3,6-dichloro-pyridazine-4-carboxylic acid (4.0 g, 20.7 mmol) is taken up in dioxane, combined with HCl (20.7 niL, IM in H2O) and stirred for 4 h at 90C. The precipitate formed is filtered off, dried and 6-chloro-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid is obtained.

51149-08-7 3,6-Dichloropyridazine-4-carboxylic acid 433804, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; McCONNELL, Darryl; STADTMUELLER, Heinz; WO2010/7114; (2010); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

51149-08-7, 3,6-dichloropyridazine-4-carboxylic acid (80.0 g, 0.41 mol), N,O-dimethylhydroxylamine hydrochloride (58.0 g, 0.59 mol) and HBTU (302.0 g, 0.80 mol) was added in dichloromethane (1.0 liters), cooled to 0 C, was added dropwise triethylamine (160.0 g, 1.58 mol), stirring was continued for 1 hour, then warmed to room temperature for 7 hours. After completion of the reaction, the reaction system was washed with water (200 ml ¡Á 3), the organic phase was concentrated under reduced pressure, the residue was purified by flash column chromatography (petroleum ether: ethyl acetate = 5: 1-1: 2 gradient elution) to give 60 g product 3,6-dichloro-N-methoxy-N-methyl-pyridazine-4-carboxamide.

51149-08-7 3,6-Dichloropyridazine-4-carboxylic acid 433804, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Hutchison Medi Pharma (Shanghai) Co., Ltd.; Su, Weiguo; Dai, Guangxiu; Zhang, Weihan; Deng, Wei; (64 pag.)CN105503877; (2016); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.135034-10-5,3-Chloro-6-iodopyridazine,as a common compound, the synthetic route is as follows.

Procedure E: General Procedure of Negishi Coupling; A bromopyridine solution (1.6 eq.) in the freshly distilled and degassed THF is cooled to -78 C. in a three-neck round-bottom flask fitted with a condenser. The butyllithium (2.5 M in hexane, 1.6 eq.) is added gently and the reaction medium is stirred for 30 minutes at -78 C. The zinc chloride solution (previously sublimated, 1.6 eq.) in the degassed THF is cannulated at -78 C. into the reaction medium. The solution is stirred at room temperature for 30 minutes, then a solution of tetrakis(triphenylphosphine) palladium (0) (0.1 eq.) and halopyridazine (1 eq.) in the THF is cannulated into the reaction medium. The solution is stirred for 48 hours at a temperature that depends on the substrate. The medium is treated with a NaHCO3 saturated solution. The solution is filtered through Celite and sequentially washed with DCM and with concentrated ammonia (25 N). The organic phase is dried over Na2SO4 and concentrated under reduced pressure.; Route 3:; This synthetic route uses the Negishi coupling of an organozinc derivative with a halogenated pyridazine. The zinc pyridine is formed in situ from 2-bromopyridine in the presence of butyllithium and zinc chloride. A solution of 3-chloro-6-iodopyridazine (103) and tetrakis(triphenylphosphine) palladium (0) is then cannulated to give a compound (8a) with a yield of 62% (initial step). Bipyridazine (19) is achieved through homocoupling., 135034-10-5

As the paragraph descriping shows that 135034-10-5 is playing an increasingly important role.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.; US2010/4443; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

135034-10-5, 3-Chloro-6-iodopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,6-Dichloro-4-(6-(ethyl(3-fluorobenzyl)amino)pyridazin-3-yl)phenol (compound 127) 3-Chloro-6-iodopyridazine (prepared as described by Goodman et al. Tetrahedron 1999, 55, 15067-15070) (100 mg, 0.42 mmol) and N-(3-fluorobenzyl)ethanamine (127 mg, 0.83 mmol) were heated in dimethylacetamide (2 mL) at 100 C. for 6 d. EtOAc (10 mL) and 1 M HCl (aqueous, 5 mL) were added and the layers were separated. The aqueous layer was extracted with EtOAc and the combined organic layers were dried (MgSO4), filtered and concentrated in vacuo leaving a brown oil (103 mg) which was used in the next step without further purification. (Note: A mixture of mono-displaced products, the iodo-displaced and the chloro-displaced compounds, were obtained at this point). The residue was dissolved in dioxan (2 mL) and PdCl2(dppf) (8 mg, 0.0095 mmol), tert-butyl(2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)dimethylsilane (83 mg, 0.21 mmol) and 1.5 M Na2CO3 solution (aqueous, 1 mL) were added. The dark mixture was heated in a sealed tube at 80 C. for 1 d. EtOAc and H2O were added and the layers separated. The aqueous layer was extracted with EtOAc and the combined organic layers were dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by preparative HPLC to afford (19.9 mg, 0.051 mmol, 12%) of the title compound. 1H NMR delta (ppm) (DMSO-d6): 1.18 (3H, t, J=6.92 Hz), 3.71 (2H, q, J=6.98 Hz), 4.92 (2H, s), 7.07-7.16 (4H, m), 7.37-7.45 (1H, m), 7.96 (1H, d, J=9.64 Hz), 8.03 (2H, s). LCMS (10 cm_esi_formic) tR 3.48 min; m/z 390 [M-H]-., 135034-10-5

As the paragraph descriping shows that 135034-10-5 is playing an increasingly important role.

Reference£º
Patent; Institute for OneWorld Health; US2009/270398; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38956-79-5,3-Hydrazinyl-6-methylpyridazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of corresponding hydrazinylpyridazine 1 or 5 (1 mmol) and aldehyde 2 (1.1 mmol) in ethanol (5 mL) was heated at 60 C for 0.5 h. The formation of hydrazone was checked by TLC and the reaction mixture was cooled to rt. Oxone (1.5 mmol) was added to the mixture at rt followed by tetramethyl ammonium bromide (0.2 mmol) and the resulting mixture was heated at 60 C for another 5 h. The mixture was cooled to rt and extracted with dichloromethane (2 ¡Á 25 mL), dried over anhydrous sodium sulfate and concentrated to obtain a residue which was purified by column chromatography using hexane/ethyl acetate as eluent to furnish the desired triazolopyridazines 4 and 7 (See reference no; 7 for supporting information).

38956-79-5, As the paragraph descriping shows that 38956-79-5 is playing an increasingly important role.

Reference£º
Article; Ruso, Jayaraman Sembian; Rajendiran, Nagappan; Srinivas, Chowdappa; Murthy, Konappa Narasimha; Soumya, Krishnamurthy; Journal of the Korean Chemical Society; vol. 58; 4; (2014); p. 377 – 380;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1120-95-2,3-Chloropyridazine,as a common compound, the synthetic route is as follows.

A mixture of 2-cloropyridazine (3 eq.) and 1,4 cyclohexane methyl amine (1 eq.) and DABC (5-Chloro-l ,3-benzenediamine) were dissolved in N-methylpyrollidone and heated over night at 120C to obtain compound 3 in 85% yield. HI NMR (400, MEOD), d =4.52(8) 5.090V) 7.38 (S) 7.82 (m)), 7.88(m), 7.91 (m), 8.12 9m), 1120-95-2

The synthetic route of 1120-95-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; WO2013/134371; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

89640-81-3, Methyl 6-oxo-1,6-dihydropyridazine-4-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.37 mL of a 4 molar aqueous sodium hydroxide solution was added to a solution of 150 mg of methyl 6-oxo-1Hpyridazine-4-carboxylate 4a in 1.5 mL methanol. The reaction mixture was stirred for 2 hours at 20 C. 0.37 mL of a 4molar hydrochloric acid are added. The precipitated product was filtered by suction, washed with water and dried at 50 C[0030] Yield: 90 mg (66 % of theory) of 6-oxo-1H-pyridazine-4-carboxylic acid 5 as a solid.[0031] 1H NMR (400 MHz, DMSO-d6) delta (ppm) 14.0 (bs, 1H), 13.4 (bs, 1H), 8.13 (d, 1H, J = 1.95 Hz), 7.23 (d, 1H, J= 1.95 Hz), 89640-81-3

89640-81-3 Methyl 6-oxo-1,6-dihydropyridazine-4-carboxylate 53249880, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; Linz, Guenter; Kraemer, Friedhelm; Schnaubelt, Juergen; Stehle, Emanuel; EP2857387; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

2166-31-6, 6-Phenylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Addition of 68.9 g of 6-phenyl-3-pyridazinone g (0.4 mol) in a 500 ml four-neck flask, prepared in Example 1Modified ZSM-5 molecular sieve 7 g, 413.4 g of phosphorus oxychloride and 166.5 g of phosphorus pentachloride (0.8 mol), and then heated to 90C, and kept warmAfter half an hour of reaction, the temperature was raised to 110C and the reaction was refluxed for 4 hours. The reaction was completed. HPLC was used to determine the area normalized to give 3-phenyl-4-one.The ratio of chloropyridazine, 3-phenyl-4-6-dichloropyridazine, 3-phenyl-4-5-dichloropyridazine was 0.5:98.4:1.1;The reaction solution was distilled under reduced pressure to remove phosphorus oxychloride, and the temperature under vacuum distillation was 120C. The degree of vacuum was -0.098 MPa;After being bundled, it is cooled to room temperature, then 137.8g of toluene is added, stirred and heated to recrystallize, the Buchner funnel is filtered, and the wet product is blownThe box was dried at 80C for 8 hours to obtain 86.5 g of a white solid-like 3-phenyl-4-6-dichloropyridazine product (HPLC: 99.7%; Yield:95.3%).

2166-31-6, As the paragraph descriping shows that 2166-31-6 is playing an increasingly important role.

Reference£º
Patent; Changzhou Woteng Chemical Technology Co., Ltd.; Wan Zhibing; Wang Zhichao; Sun Kezhou; Liu Rong; (5 pag.)CN106831600; (2017); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

51149-08-7, Example 5( 6-Chloro-1 H -indol-3-yl)[ 6-chloro-[3-( 4-.fluorobenzyl)amino ]pyridazin-4-yl]methanone 3,6-Dichloropyridazine-4-carbonyl chloride. 3,6-Dichloropyridazine-4-carboxylic acid (Aldrich; 1.13 g, 5.86 mmol) in toluene (20 mL) containing 2 drops of DMF was treated with neat SOCI2 (4 mL). The mixture heated to reflux for 3h and then allowed to cool. The resulting red-orange mixture was decanted and cone, in vacuo. The residue was redis solved in toluene and cone to give 1.22 g of the product.

51149-08-7 3,6-Dichloropyridazine-4-carboxylic acid 433804, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; HOGENKAMP, Derk; WO2013/169907; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

Preparation 9.1: 5-(4-methylpiperazin-l-yl)pyridazin-4-amine 7o Step 1: 3,4-dichloro-5-(4-methylpiperazin-l-yl)pyridazine [00283] 3,4,5-Trichloropyridazine (3 g, 16.36 mmol) was dissolved in dry NMP (18 mL) and cooled in an ice-bath. DIPEA (2.326 g, 3.135 mL, 18 mmol) was added, followed, dropwise, by 1-methylpiperazine (1.721 g, 1.906 mL, 17.18 mmol). The resulting mixture was stirred at RT overnight. The reaction mixture was concentrated under reduced pressure to give an brown solid whichwas partitioned between 10% MeOH in DCM and saturated NaHC03. The aqueous layer was extracted with further 10% MeOH in DCM (5x20mL) and the combined organics were dried over Na2S04, filtered and concentrated under reduced pressure to give a brown oil which was purified by column chromatography (7.5% MeOH in DCM, ~300mL silica, loaded in DCM) to provide 3,4-dichloro-5-(4-methylpiperazin-l- yl)pyridazine as a light yellow solid (2.36g, 58% Yield)., 14161-11-6

The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; BRENCHLEY, Guy; CHARRIER, Jean-damien; DAVIS, Chris; DURRANT, Steven; JARDI, Gorka, Etxebarria I; FRAYSSE, Damien; JIMENEZ, Juan-miguel; KAY, David; KNEGTEL, Ronald; PIERARD, Francoise; PINDER, Joanne; SHAW, David; STORCK, Pierre-henri; STUDLEY, John; TWIN, Heather; WO2014/143241; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem