Month: October 2020

63001-30-9, Methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

63001-30-9, B. A mixture of 6-hydroxypyridazine-3-carboxylic acid methyl ester obtained above and phosphorous oxychloride were carefully heated to reflux and maintained there for 2.5 h. The reaction mixture was then cooled and evaporated in vacuo to remove excess phosphorylchloride, and the residue was then poured into ice water. The precipitate was collected by filtration, washed with saturated NaHCO3 and water, and dried under vacuum to yield the product as a yellow solid (4.359 g, 79% yield).

The synthetic route of 63001-30-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; XENON PHARMACEUTICALS INC.; WO2006/34440; (2006); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the compound of preparation 92 (30mg, 0.057mmol) in acetonitrile (1 OmL) were added 3-chloro-6-cyanopyridazine (12mg, 0.086mmol) and N,N-diisopropylethylamine (40muL, 0.23mmol). The reaction mixture was stirred at reflux for 3h. The reaction was concentrated in vacuo and residue diluted by adding sodium hydrogen carbonate solution (1 OmL) and extracted with EtOAc (3 x 1 OmL). The combined organic extracts were washed with brine (15ml_), dried with sodium sulphate, filtered and concentrated in vacuo to give the crude residue. Purification by column chromatography on silica gel using dichloromethane:methanol:0.88 ammonia (95:5:0.5) gave 25mg (78%) of the title compound as a mixture of epimers as a white solid. 1H NMR (400 MHz, CD3OD) delta 1.19 -2.47 (1 OH, m), 2.87-4.49 (12H, m), 4.80- 4.85 (1 H, m), 6.52-6.69 (3H, m), 6.92-6.94 (2H, m), 7.09-7.37 (3H, m), 7.42- 7.47 (1 H, m). LRMS: APCI+ m/z 627 [MH+]., 35857-89-7

35857-89-7 6-Chloropyridazine-3-carbonitrile 13382871, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER LIMITED; ANDREWS, Mark, David; BARBER, Christopher, Gordon; WO2010/15972; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

3-Chloro-6-methylpyridazine (3.00 g, 23.3 mmol) was dissolved in concentrated sulfuric acid (23 mL), and potassium dichromate (8.24 g, 28.0 mmol) was added little by little under ice cooling. The mixture was stirred at room temperature for 1.5 hours, and the mixture was further stirred at 50C for 60 hours. The reaction mixture was slowly poured into ice water, and the mixture was extracted with diethyl ether (x 3). The organic layer was washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure to give the title compound (1.27 g; yield, 34%) as a white solid. 1H NMR (CDCl3, 400 MHz): delta 7.80 (1H, d, J = 7.8 Hz), 8.32 (1H, d, J = 7.8 Hz). MS (ESI) m/z: 159 (M+H) +.

1121-79-5, 1121-79-5 3-Chloro-6-methylpyridazine 227254, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2409977; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

14305-08-9, 4,5-Dibromo-2-phenylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Using a published method,26 a solution of 2-phenyl-4,5-dibromopyridazin-3(2H)-one (30) (1.043g, 3.16mmol, 1.00 equiv) in THF (23mL) was cooled to -20C and treated with one portion of (i-Pr) MgCl (2M in THF, 1.58mL, 3.16mmol, 1.00 equiv) to give a very dark red-brown solution. After exactly 3min the reaction was quenched by addition of water (0.570muL, 31.61mmol, 10.00 equiv), allowed to warm to 20C over 145min, then poured into saturated aqueous NH4Cl solution. The mixture was extracted with CH2Cl2 (¡Á4), and the combined extracts were dried (MgSO4) and concentrated to dryness under reduced pressure. The dark orange residue was purified by column chromatography on silica gel, eluting with 0-30% EtOAc/hexanes, to give 51 (0.229g, 25%) as a yellow oil: 1H NMR (CDCl3): 7.91 (s, 1H), 7.54 (m, 2H), 7.47 (m, 2H), 7.39 (m, 1H), 3.48 (sept, J=6.9Hz, 1H), 1.40 (d, J=7.0Hz, 6H); LRMS (APCI+): m/z [M+H]+ 295.4 (81Br, 80%), 293.4 (79Br, 100%); TLC Rf=0.70 (20% EtOAc/hexanes)., 14305-08-9

The synthetic route of 14305-08-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Brooke, Darby G.; Van Dam, Ellen M.; Watts, Colin K.W.; Khoury, Amanda; Dziadek, Marie A.; Brooks, Hilary; Graham, Lisa-Jane K.; Flanagan, Jack U.; Denny, William A.; Bioorganic and Medicinal Chemistry; vol. 22; 3; (2014); p. 1029 – 1039;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5788-58-9, 4,5-Dibromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4,5-dibromopyridazin-3(2H)-one (0.30 g, 1.182 mmol), 2-(piperidin-4- yl)benzonitrile hydrochloride (0.289 g, 1.300 mmol), and DIPEA (0.454 ml, 2.60 mmol) in DMA (2.498 ml) was heated to 100C for 16h. The reaction was cooled and diluted with saturated sodium bicarbonate to give a tan precipitate that was filtered and dried to give 2-(l-(5-bromo-6-oxo-l,6-dihydropyridazin-4-yl)piperidin-4- yl)benzonitrile (0.434 g, 100%). LCMS: Rt = 0.85 min, (M+H)+ = 359.7. The material was used without purification, 5788-58-9

5788-58-9 4,5-Dibromopyridazin-3(2H)-one 236181, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Dissolve 25.Og (0.229 moles) of 3-chloro-6-methylpyridazine in 250 ml of NH4OH and heat to 1700C. in a sealed container for 24 h. Evaporate solvents. Triturate in methylene chloride and filter solid. Repeat with filtrate 4 x. Combine all filtered solids and dry in vacuum oven over night to obtain product as off-white solid 4.32 g (0.040 moles, 20.4 %). H1NMR (DMSO-d6): delta 7.1 (d, J = 8.9 Hz, IH); 6.67 (d, J = 6.67 Hz, IH); 6.04 (s, br, 2H); 2.33 (s, 3H) ppm. ES+ = 110 (100%, M + 1).

1121-79-5, The synthetic route of 1121-79-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2006/107784; (2006); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

51149-08-7, 3,6-Dichloropyridazine-4-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of 3,6-dichloropyridazine-4-carboxylic acid (15.0 g, 78 mmol) in THF (150 mL) was added ethanol (18.15 mL, 311 mmol) and DMAP (0.950 g, 7.77 mmol). EDC (16.39 g, 85 mmol) was then added in portions over 1 min. The reaction was mildly exothermic. The reaction was stirred at room temperature for 16 h. The reaction mixture was transferred to a separatory funnel containing saturated aqueous NaHCCb solution (150 mL). The aqueous layer was extracted with ether (3 x 250 mL). The combined organic layers were washed with brine (100 mL), dried over MgSCn, filtered, and concentrated. The residue was purified by column chromatography on silica gel (20%? 40% ethyl acetate in hexanes; 300 g column) to afford ethyl 3,6-dichloropyridazine-4- carboxylate (13.2 g, 59.7 mmol, 77% yield) as a colorless oil: NMR (400MHz, CDCh) delta 7.88 (s, 1H), 4.50 (q, J=7.0 Hz, 2H), 1.46 (t, J=7.2 Hz, 3H); LCMS (ESI) m/e 221.1 [(M+H)+, calcd for C7H7CI2N2O2 221.0].

51149-08-7, 51149-08-7 3,6-Dichloropyridazine-4-carboxylic acid 433804, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; HARTZ, Richard A.; AHUJA, Vijay T.; SIVAPRAKASAM, Prasanna; DUBOWCHIK, Gene M.; MACOR, John E.; (104 pag.)WO2018/98411; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.

PREPARATION 16; 3-Bromo-6-chloro-7-methylimidazo[1,2- )]pyridazine a) 6-Chloro-5-methylpyridazin-3-amine (+ 6-chloro-4-methylpyridazin-3-amine) Ammonia (32% solution in water, 54 mL) was added to a solution of 3,6-dichloro-4- methylpyridazine (5.0 g, 30.67 mmol) in ethanol (25 mL) in a sealed tube. The resulting mixture was stirred at 100 C for 70 hours, cooled down and the solvent was removed under reduced pressure. The residue was purified by flash chromatography (3:2 hexanes/ethyl acetate to 100% ethyl acetate) to yield the title compound (3.8 g, 57%) as a mixture of two isomers which was used in the next step without further purification.LRMS (m/z): 144 (M+1)+.

19064-64-3, 19064-64-3 3,6-Dichloro-4-methylpyridazine 87923, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; ALMIRALL,S.A.; GONZALEZ RODRIGUEZ, Jacob; VIDAL JUAN, Bernat; VIDAL GISPERT, Laura; BACH TANA Jordi; WO2012/69202; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65202-50-8,Methyl 6-chloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.

65202-50-8, Step 5; Methyl 6-(4-[2-(trifluoromethyl)benzoyl]piperazin-l-yUpyrida2ine-3-carboxylate; To a mixture of methyl -chloropyridazine-S-carboxylate (3.9 g, 22.6 mmol), l-[2- (trifluoromethyl)benzoyl]piperazine (7.0 g, 27.1 mmol) and potassium carbonate (6.5 g, 47 mmol) was added 100 mL of dioxane and the mixture was heated to reflux for 71 h. The mixture was cooled to room temperature and the solid filtered and swirled in 4: 1 ethepiethyl acetate at reflux for 45 min. The solid was filtered to provide the title compound.

The synthetic route of 65202-50-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/9236; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

15456-86-7, 4-Bromo-1,2-dihydropyridazine-3,6-dione is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a degassed solution of 4-bromo-1,2-dihydropyridazine-3,6-dione (100 mg, 0.5 mmol), (4-fluoro-1H-indol-2-yl)boronic acid (131 mg, 0.7 mmol) and K3P04 (279 mg, 1.1 mmol) in DMF (2 mL) and H20 (0.2 mL) was added Pd(dppf)Cl2 (5 mg) under N2. The mixture was stirred at 80 C for 12 h. After the solvent was removed, the residue was purified by prepTLC (DCM : EtOAc = 10: 1) to give the product of 4-(4-fluoro-1H-indol-2-yl)-1,2-dihydropyridazine-3,6-dione (50 mg, yield: 39%). ?H-NMR (DMSO-d6, 400 MHz,) 11.95 (br.s, 1H), 7.47-7.68 (m, 3H), 7.35 (d, J= 8.0 Hz, 1H), 7.1 1-7.19 (m, 1H), 6.81 (dd, J= 8.0, 10.4Hz, 1H). MS (M+H): 246., 15456-86-7

The synthetic route of 15456-86-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; BROCKUNIER, Linda, L.; NARGUND, Ravi; MARCANTONIO, Karen; ZORN, Nicolas; XIAO, Dong; PENG, Xuanjia; LI, Peng; GUO, Tao; WO2014/123793; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem