With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141-30-0,3,6-Dichloropyridazine,as a common compound, the synthetic route is as follows.
Vl.i .a3-Benzyloxy-6-chloro-pyridazine; 33.92 g (205.5 mmol) 3,6-Dichloro-pyridazine are dissolved in 100 ml benzyl alcohol and30.06 g (231.0 mmol) sodium benzylate are added. The mixture is stirred for 30 minutes atRT. After that time the mixture is slowly poured into ice water, the precipitate is filtered off and washed with water. The product is dried at 80C.Yield: 1 1.5 g (81 % of theory), Rf value: 0.60 (silica gel, cyclohexane/tehyl acetate = 2:1 )EII Mass spectrum: m/z = 243/245 [M+Na]+, 141-30-0
As the paragraph descriping shows that 141-30-0 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2007/48802; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem