With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.825633-94-1,5-Iodo-2,3-dihydropyridazin-3-one,as a common compound, the synthetic route is as follows.
5-Iodopyridazin-3 (2H) -one (200 mg, 0.90 mmol) , potassium carbonate (249 mg, 1.80 mmol) , and anhydrous acetonitrile (4.5 mL) were charged to a round-bottom flask equipped with a rubber septum and magnetic stirbar. Methyl iodide (62.0 muL, 0.991 mmol) was charged dropwise via syringe. The flask was then equipped with a reflux condenser and heated at reflux for 1 hour. The reaction mixture was filtered through. The filtrate was evaporated to give the crude product, which was purified by silica gel column chromatography (0-10 MeOH/DCM) to afford 5-iodo-2-methylpyridazin-3 (2H) -one. LC/MS: (M+1) +: 236.80., 825633-94-1
The synthetic route of 825633-94-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DONG, Shuzhi; GU, Xin; JIANG, Jinlong; SHI, Zhi-Cai; WALSH, Shawn P.; WU, Zhicai; YU, Yang; FERGUSON II, Ronald; GUO, Zhiqiang; FRIE, Jessica; SUZUKI, Takao; BLIZZARD, Timothy A.; FU, Qinghong; VANGELDER, Kelsey F.; (118 pag.)WO2016/65582; (2016); A1;,
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