With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16401-70-0,N-Methylpyridazin-4-amine,as a common compound, the synthetic route is as follows.
To a solution of N-methylpyridazin-4-amine (83 mg, 0.76 mmol), triethylamine (0.42 ml, 3.04 mmol)and a catalytic amount of DMAP in 15 ml THE was added a solution in CH2Cl2 (5 ml) of 1-(6-chloro-3-methyl-2-pyridyl)-5-methyl-pyrazole-4-carbonyl chloride (0.21 g, 0.76 mmol), prepared from thecorresponding acid (oxalyl chloride 5 eq., CH2Cl2, cat. DMF, 40C,5 h). The mixture was stirred at rtovernight. After evaporation of the solvents, the residue was taken up in ethyl acetate and washedwith a solution of sodium bicarbonate. After drying (MgSO4) and evaporating the organic phase, theresidue was purified by flash chromatography to give the title compound as white crystals. Mp: 190-4C, LCMS: 0.69 min, 343-5 (MH)., 16401-70-0
As the paragraph descriping shows that 16401-70-0 is playing an increasingly important role.
Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; HALL, Roger Graham; EDMUNDS, Andrew; JEANGUENAT, Andre; WO2014/166795; (2014); A1;,
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