1206487-35-5, 4,6-Dibromopyridazin-3-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 2-bromo- 1 -((lr,3 r)-3- (quinolin-2-yl)cyclobutyl)ethanone (1.56 g, 4.62 mmol, prepared using themethod described in Example 1, step C) and 4,6-dibromopy-ridazin-3-amine (1.17 g, 4.62 mmol) in DMF (10 mE) wasstirred at rt for 3 days. The reaction mixture was poured intowater (200 mE), and extracted with EtOAc (2×200 mE). The combined organic layers were washed with saturated NaHCO3 and brine, dried over Na2 SO4, filtered, and concentrated. The residue obtained was purified by flash chromatography on silica gel (0-40% EtOAc/heptane) to obtain 2-((lr, 3r)-3-(6,8-dibromoimidazo[ 1 ,2-b]pyridazin-2-yl)cyclobutyl)quinoline as a yellow oil. ?H-NMR (400 MHz, CDC13) oe (ppm): 8.10 (dd, J=8.3, 4.8 Hz, 2H), 7.98 (s, 1H), 7.79 (d, J=8.1 Hz, 1H), 7.70 (t, J=7.8 Hz, 1H), 7.47-7.53 (m, 1H), 7.44 (s, 1H), 7.38 (d, J=8.6 Hz, 1H), 4.01-4.10 (m, 1H),3.89-3.99 (m, 1H), 2.96-3.08 (m, 2H), 2.75-2.86 (m, 2H).
1206487-35-5, The synthetic route of 1206487-35-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Janssen Pharmaceutica, NV; Player, Mark R.; Meegalla, Sanath K.; Illig, Carl R.; Chen, Jinsheng; Wilson, Kenneth J.; Lee, Yu-Kai; Parks, Daniel J.; Cheung, Wing S.; Huang, Hui; Patch, Raymond J.; US2014/364413; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem