51149-08-7, 3,6-Dichloropyridazine-4-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of 3,6-dichloropyridazine-4-carboxylic acid (15.0 g, 78 mmol) in THF (150 mL) was added ethanol (18.15 mL, 311 mmol) and DMAP (0.950 g, 7.77 mmol). EDC (16.39 g, 85 mmol) was then added in portions over 1 min. The reaction was mildly exothermic. The reaction was stirred at room temperature for 16 h. The reaction mixture was transferred to a separatory funnel containing saturated aqueous NaHCCb solution (150 mL). The aqueous layer was extracted with ether (3 x 250 mL). The combined organic layers were washed with brine (100 mL), dried over MgSCn, filtered, and concentrated. The residue was purified by column chromatography on silica gel (20%? 40% ethyl acetate in hexanes; 300 g column) to afford ethyl 3,6-dichloropyridazine-4- carboxylate (13.2 g, 59.7 mmol, 77% yield) as a colorless oil: NMR (400MHz, CDCh) delta 7.88 (s, 1H), 4.50 (q, J=7.0 Hz, 2H), 1.46 (t, J=7.2 Hz, 3H); LCMS (ESI) m/e 221.1 [(M+H)+, calcd for C7H7CI2N2O2 221.0].
51149-08-7, 51149-08-7 3,6-Dichloropyridazine-4-carboxylic acid 433804, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; HARTZ, Richard A.; AHUJA, Vijay T.; SIVAPRAKASAM, Prasanna; DUBOWCHIK, Gene M.; MACOR, John E.; (104 pag.)WO2018/98411; (2018); A1;,
Pyridazine – Wikipedia
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