35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of the compound of preparation 92 (30mg, 0.057mmol) in acetonitrile (1 OmL) were added 3-chloro-6-cyanopyridazine (12mg, 0.086mmol) and N,N-diisopropylethylamine (40muL, 0.23mmol). The reaction mixture was stirred at reflux for 3h. The reaction was concentrated in vacuo and residue diluted by adding sodium hydrogen carbonate solution (1 OmL) and extracted with EtOAc (3 x 1 OmL). The combined organic extracts were washed with brine (15ml_), dried with sodium sulphate, filtered and concentrated in vacuo to give the crude residue. Purification by column chromatography on silica gel using dichloromethane:methanol:0.88 ammonia (95:5:0.5) gave 25mg (78%) of the title compound as a mixture of epimers as a white solid. 1H NMR (400 MHz, CD3OD) delta 1.19 -2.47 (1 OH, m), 2.87-4.49 (12H, m), 4.80- 4.85 (1 H, m), 6.52-6.69 (3H, m), 6.92-6.94 (2H, m), 7.09-7.37 (3H, m), 7.42- 7.47 (1 H, m). LRMS: APCI+ m/z 627 [MH+]., 35857-89-7
35857-89-7 6-Chloropyridazine-3-carbonitrile 13382871, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; PFIZER LIMITED; ANDREWS, Mark, David; BARBER, Christopher, Gordon; WO2010/15972; (2010); A1;,
Pyridazine – Wikipedia
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