With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65202-50-8,Methyl 6-chloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.
65202-50-8, Step 5; Methyl 6-(4-[2-(trifluoromethyl)benzoyl]piperazin-l-yUpyrida2ine-3-carboxylate; To a mixture of methyl -chloropyridazine-S-carboxylate (3.9 g, 22.6 mmol), l-[2- (trifluoromethyl)benzoyl]piperazine (7.0 g, 27.1 mmol) and potassium carbonate (6.5 g, 47 mmol) was added 100 mL of dioxane and the mixture was heated to reflux for 71 h. The mixture was cooled to room temperature and the solid filtered and swirled in 4: 1 ethepiethyl acetate at reflux for 45 min. The solid was filtered to provide the title compound.
The synthetic route of 65202-50-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/9236; (2007); A1;,
Pyridazine – Wikipedia
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