14305-08-9, 4,5-Dibromo-2-phenylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Using a published method,26 a solution of 2-phenyl-4,5-dibromopyridazin-3(2H)-one (30) (1.043g, 3.16mmol, 1.00 equiv) in THF (23mL) was cooled to -20C and treated with one portion of (i-Pr) MgCl (2M in THF, 1.58mL, 3.16mmol, 1.00 equiv) to give a very dark red-brown solution. After exactly 3min the reaction was quenched by addition of water (0.570muL, 31.61mmol, 10.00 equiv), allowed to warm to 20C over 145min, then poured into saturated aqueous NH4Cl solution. The mixture was extracted with CH2Cl2 (¡Á4), and the combined extracts were dried (MgSO4) and concentrated to dryness under reduced pressure. The dark orange residue was purified by column chromatography on silica gel, eluting with 0-30% EtOAc/hexanes, to give 51 (0.229g, 25%) as a yellow oil: 1H NMR (CDCl3): 7.91 (s, 1H), 7.54 (m, 2H), 7.47 (m, 2H), 7.39 (m, 1H), 3.48 (sept, J=6.9Hz, 1H), 1.40 (d, J=7.0Hz, 6H); LRMS (APCI+): m/z [M+H]+ 295.4 (81Br, 80%), 293.4 (79Br, 100%); TLC Rf=0.70 (20% EtOAc/hexanes)., 14305-08-9
The synthetic route of 14305-08-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Brooke, Darby G.; Van Dam, Ellen M.; Watts, Colin K.W.; Khoury, Amanda; Dziadek, Marie A.; Brooks, Hilary; Graham, Lisa-Jane K.; Flanagan, Jack U.; Denny, William A.; Bioorganic and Medicinal Chemistry; vol. 22; 3; (2014); p. 1029 – 1039;,
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