With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20698-04-8,3,6-Diiodopyridazine,as a common compound, the synthetic route is as follows.
1.10. a Benzyl-(6-iodo-pyridazin-3-yl)-amine471 mg (10,8 mmol) sodium hydride (55%) are added at O0C under nitrogen atmosphere to a mixture of 1 ,084 ml (9,8 mmol) benzylamine and 25 ml dry DMF. The reaction mixture is stirred for one hour at room temperature. Then 3,26 g (9,8 mmol) 3,6-diiodo-pyridazine are added and the reaction mixture is stirred at 1000C for 18 hours. The reaction mixture is concentrated. Methylene chloride is added to the residue and the mixture is extracted with water. The organic phase is dried over sodium sulphate and concentrated. Purification is achieved by silica gel column chromatography with petrol ether/ EtOAc as eluent. Yield: 0,23 g (8% of theory),Rf value: 0.55 (silica gel, petrol ether/ EtOAc = 1 :1 ), 20698-04-8
The synthetic route of 20698-04-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/71646; (2008); A1;,
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