With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.
Step 9.1. 6-Chloro-4-methylpyridazin-3-ylamine and 6-chloro-5-methylpyridazin-3-ylamine A mixture of 50.0 g (307 mmol) of 3,6-dichloro-4-methylpyridazine in 170 ml of aqueous ammonia (30%) is heated at 120 C. for 16 h in a steel reactor at the internal pressure of bar.The reactor is cooled and the reaction mixture is poured into 200 ml of water. The solid formed is isolated by filtration and dried under vacuum, to give 38.5 g of a mixture containing approximately 45% of 6-chloro-4-methylpyridazin-3-ylamine (CAS 64068-00-4) and 55% of 6-chloro-5-methylpyridazin-3-ylamine (CAS 66346-87-0).1H NMR (CDCl3) delta: 7.20 and 6.75 (2s, 1H): (d, 0.55H), 4.9 (sl, 2H), 2.40 and 2.25 (2s, 3H) ppm., 19064-64-3
As the paragraph descriping shows that 19064-64-3 is playing an increasingly important role.
Reference£º
Patent; SANOFI-AVENTIS; US2011/312934; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem