With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
51149-08-7, 3,6-dichloropyridazine-4-carboxylic acid (80.0 g, 0.41 mol), N,O-dimethylhydroxylamine hydrochloride (58.0 g, 0.59 mol) and HBTU (302.0 g, 0.80 mol) was added in dichloromethane (1.0 liters), cooled to 0 C, was added dropwise triethylamine (160.0 g, 1.58 mol), stirring was continued for 1 hour, then warmed to room temperature for 7 hours. After completion of the reaction, the reaction system was washed with water (200 ml ¡Á 3), the organic phase was concentrated under reduced pressure, the residue was purified by flash column chromatography (petroleum ether: ethyl acetate = 5: 1-1: 2 gradient elution) to give 60 g product 3,6-dichloro-N-methoxy-N-methyl-pyridazine-4-carboxamide.
51149-08-7 3,6-Dichloropyridazine-4-carboxylic acid 433804, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; Hutchison Medi Pharma (Shanghai) Co., Ltd.; Su, Weiguo; Dai, Guangxiu; Zhang, Weihan; Deng, Wei; (64 pag.)CN105503877; (2016); A;,
Pyridazine – Wikipedia
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