With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.
Preparation 9.1: 5-(4-methylpiperazin-l-yl)pyridazin-4-amine 7o Step 1: 3,4-dichloro-5-(4-methylpiperazin-l-yl)pyridazine [00283] 3,4,5-Trichloropyridazine (3 g, 16.36 mmol) was dissolved in dry NMP (18 mL) and cooled in an ice-bath. DIPEA (2.326 g, 3.135 mL, 18 mmol) was added, followed, dropwise, by 1-methylpiperazine (1.721 g, 1.906 mL, 17.18 mmol). The resulting mixture was stirred at RT overnight. The reaction mixture was concentrated under reduced pressure to give an brown solid whichwas partitioned between 10% MeOH in DCM and saturated NaHC03. The aqueous layer was extracted with further 10% MeOH in DCM (5x20mL) and the combined organics were dried over Na2S04, filtered and concentrated under reduced pressure to give a brown oil which was purified by column chromatography (7.5% MeOH in DCM, ~300mL silica, loaded in DCM) to provide 3,4-dichloro-5-(4-methylpiperazin-l- yl)pyridazine as a light yellow solid (2.36g, 58% Yield)., 14161-11-6
The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; BRENCHLEY, Guy; CHARRIER, Jean-damien; DAVIS, Chris; DURRANT, Steven; JARDI, Gorka, Etxebarria I; FRAYSSE, Damien; JIMENEZ, Juan-miguel; KAY, David; KNEGTEL, Ronald; PIERARD, Francoise; PINDER, Joanne; SHAW, David; STORCK, Pierre-henri; STUDLEY, John; TWIN, Heather; WO2014/143241; (2014); A1;,
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