With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7252-84-8,3-Amino-6-methoxypyridazine,as a common compound, the synthetic route is as follows.
Example 62: Preparation of 2-{3-[2-(4-chlorophenyl)ethyl]-5-oxo-l-phenyl-2- sulfanylideneimidazolidin-4-yl}-N-(6-methoxypyridazin-3-yl)acetamide. TBTU (253.3 mg; 0.77 mmol; 1.5 eq) and DIPEA (179 mu 1-03 mmol; 2 eq) were added to a solution of 2-{3-[2-(4-chlorophenyl)ethyl]-5-oxo-l-phenyl-2- sulfanylideneimidazolidin-4-yl} acetic acid (1-3) (200 mg; 0.51 mmol; 1 eq) in dioxane (5 mL). After 20 minutes, 6-methoxypyridazin-3-amine (128.9 mg; 1.03 mmol; 2 eq) in dimethylformamide (0.1 mL) was added. The reaction mixture was stirred at room temperature over the week-end. After concentration to dryness, saturated ammonium chloride (30 mL) was added and the aqueous layer was extracted with ethyl acetate (3 x 30 mL). The combined organic layers were washed with saturated sodium chloride (3 x 30 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The crude was precipitated in methanol. The title compound, the title compound 2-{3-[2-(4-chlorophenyl)ethyl]-5-oxo-l-phenyl- 2-sulfanylideneimidazolidin-4-yl } -N-(6-methoxypyridazin-3-yl)acetamide was obtained in 22% yield (55.8 mg) as a grey-white powder. 1H-NMR (CDC13): delta (ppm) 2.9 (m, 1H), 3.03 (m, 1H), 3.22 (m, 1H), 3.45 (m, 1H), 3.74 (m, 1H), 3.98 (s, 3H), 4.17 (m, 1H), 4.8 (t, 1H, J = 4.2 Hz), 7.38 (m, 10H), 8.17 (m, 1H), 11.19 (s, 1H); MS (ESI+): m/z = 495.9, 497.8 [M+H]+ ., 7252-84-8
As the paragraph descriping shows that 7252-84-8 is playing an increasingly important role.
Reference£º
Patent; VIVALIS; GUEDAT, Philippe; BERECIBAR, Amaya; CIAPETTI, Paola; VENKATA PITHANI, Subhash; TROUCHE, Nathalie; WO2013/171281; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem