With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.
To a solution of 2H-tetrazole (1.83 1 g, 26.1 mmol) in DMF (30 ml) was added Cs2CO3(8.52 g, 26.1 mmol) at 0 C. The resulting solution was stirred at 0 C for 15 mm followed byaddition of 6-chloropyridazine-3-carbonitrile (Liu, et al., I Med. Chem. 2007, 50, 3086-3 100) (3.04 g, 21.79 mmol). The resulting solution was stirred at rt for 30 mm, then heated at 90 C for 30mm. The mixture was cooled to rt, and partitioned between EtOAc and sat. NaHCO3. The organic layer was washed with sat.NaHCO3 three times, dried over Na2504, and concentrated.The residue was stirred with DCM. The solid was collectted by filtration to give the title compound., 35857-89-7
As the paragraph descriping shows that 35857-89-7 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; BISWAS, Dipshikha; DING, Fa-Xiang; DONG, Shuzhi; GU, Xin; JIANG, Jinlong; PASTERNAK, Alexander; SUZUKI, Takao; VACCA, Joseph; XU, Shouning; WO2015/103756; (2015); A1;,
Pyridazine – Wikipedia
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