19064-65-4, 3-Methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Reagent 53-Methoxy-4-(tributylstannyl)pyridazine2,2,6,6-Tetramethylpiperidine (10.4 mL, 61.51 mmol) in ether (125 mL) was cooled to -30 C. and treated with n-BuLi (24.6 mL, 61.51 mmol). The reaction solution was warmed to room temperature for 30 minutes, and then cooled to -75 C. 3-Methoxypyridazine (3.10 g, 26.75 mmol) in ether (10 mL) was added slowly at -75 C. After ten minutes, tributylchlorostannane (10.45 g, 32.09 mmol) was added all at once and stirred at -75 C. for another forty-five minutes. The reaction was queched with a mixture of wet ether (50 mL)/saturated NH4Cl (50 mL), warmed to RT, diluted with ether (1000 mL) and washed with half-saturated NH4C twice The organic layer was dried through MgSO4, filtrated and evaporated to dry to give a yellow oil. The crude material was added to a silica gel column and was eluted with 0-20% ethyl acetate in hexane to give a blue liquid (2.09 g, 19.58% yield) as the title compound. 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 8.68 (d, J=4.2 Hz, 1 H) 7.43 (d, J=4.2 Hz, 1 H) 4.09 (s, 3 H) 1.44-1.57 (m, 6 H) 1.31 (sextet, J=7.3 Hz, 6 H) 0.99-1.23 (m, 6 H) 0.88 (t, J=7.2 Hz, 8 H. MS APCI, m/z=397/399/401 (M+H). HPLC 4.04 min.
19064-65-4, The synthetic route of 19064-65-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; US2008/318943; (2008); A1;,
Pyridazine – Wikipedia
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