1121-79-5 3-Chloro-6-methylpyridazine 227254, apyridazine compound, is more and more widely used in various fields.
1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE l; EPO 2-(6-(4-[2-(rTrifluoromethyl’)benzoyl1piperazin-l-v?pyridazin-3-yl)-l,3-benzothiazole; Step 1; 6-Chloropyridazine-3 -carboxylic acid; To concentrated sulfuric acid (175 mL) in a flask equipped with a mechanical stirrer was added 3-chloro-6-methylpyridazine (25 g, 194 mmol). To the resulting solution was added K2Cr2O7 (69 g, 234 mmol) portionwise over 40 min, using a cold water bath to maintain the internal temperature below 65 0C. The reaction was then maintained at 60 0C for 3 h. The mixture was cooled and quenched by the addition of ice, then poured onto 200 g ice and extracted eight times with EtOAc. The combined organic layers were washed with brine, dried over MgSO4 and evaporated to give the title compound., 1121-79-5
1121-79-5 3-Chloro-6-methylpyridazine 227254, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/9236; (2007); A1;,
Pyridazine – Wikipedia
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