120276-59-7, 3-Chloro-6-(chloromethyl)pyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
120276-59-7, A mixture of 3-chloro-6- (chloromethyl)pyridazine (835 mg, 5.12 mmol) and NaN3 (433 mg, 6.66 mmol) in DMF (10 mL) was stirred overnight at RT. Water was added and the mixture was extracted with EtOAc (3x). The combined organic layers were washed with brine, dried over anh. Na2S04, filtered and concentrated. The crude material was purified by silica gel chromatography (0-50% EtOAc in hexanes) to provide 3-(azidomethyl)-6- chloropyridazine (700 mg, 4.13 mmol, 81% yield) as an off-white solid. MS (ESI, pos. ion) m/z: 170.0 (M+l). .H NMR (400 MHz, CDC13) delta ppm 7.57 (s, 2 H), 4.76 (s, 2 H).
The synthetic route of 120276-59-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AMGEN INC.; D’AMICO, Derin C.; HERBERICH, Bradley J.; JACKSON, Claire L.M.; PETTUS, Liping H.; TASKER, Andrew; WANG, Hui-Ling; WU, Bin; WURZ, Ryan; WO2012/148775; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem