51355-94-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51355-94-3,6-Bromopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
6-Bromopyridazin-3(2h)-one (0.57 mmol), triphenylphosphine (1.14 mmol), and di-tert-butyl azodicarboxylate (0.855 mmol) were placed in a vial and dissolved in dichloromethane. N,N-dimethylethanolamine (0.684 mmol) was added at once. After stirring overnight, the reaction was concentrated. The residue was purified by ISCO silica flash chromatography using a dichloromethane:methanol solvent system. The desired product eluted at 8% methanol. Fractions containing the desired product were concentrated to give 6-bromo-2-(2-(dimethylamino)ethyl)pyridazin-3(2H)-one as a white solid (60 mg, 42%).
As the paragraph descriping shows that 51355-94-3 is playing an increasingly important role.
Reference£º
Patent; OHIO STATE INNOVATION FOUNDATION; THE BRIGHAM AND WOMEN’S HOSPITAL, INC.; HODGETTS, Kevin; LIN, Chien-Liang, Glenn; (0 pag.)WO2019/236625; (2019); A1;,
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