With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13327-27-0,6-Methylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
13327-27-0, 6-Methylpyridazin-3(2H)-one (Alfa, 2.5 g, 22.70 mmol) and phosphorus oxybromide (Aldrich, 16.27 g, 56.8 mmol) were heated at 90 C under a nitrogen atmosphere for 1.5 hours. After cooling, the mixture was poured onto ice (100 g), neutralized with sodium bicarbonate, and the aqueous phase was extracted with CH2Cl2 (3chi30 mL). The combined organic phase was washed with 5% NaHCO3, brine, dried (Na2SO4) and concentrated. The residue was dissolved in hot ethyl acetate and washed through a plug of silica gel, eluting with ethyl acetate and concentrated. MS (DCI/NH3) m/z 172 (M+H)+, 190 (M+NH4)+.
13327-27-0 6-Methylpyridazin-3(2H)-one 83346, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; ABBOTT LABORATORIES; SCHRIMPF, Michael R.; LEE, Chih-Hung; LI, Tao; GFESSER, Gregory A.; MORTELL, Kathleen H.; FAGHIH, Ramin; NERSESIAN, Diana L.; SIPPY, Kevin B.; BUNNELLE, William H.; SCANIO, Marc; SHI, Lei; GOPALAKRISHNAN, Murali; DONNELLY-ROBERTS, Diana; HU, Min; WO2010/36998; (2010); A2;,
Pyridazine – Wikipedia
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