35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Coupling according to general procedure II:Amine intermediate: {(3S,4R)-3-(4-Chloro-phenyl)-4-[1-((S)-5-chloro-pyridin-2-yloxy)-ethyl]pyrrolidin-1-yl}-piperidin-4-yl-methanone (VIII-B-1)Heteroaryl: 6-Chloro-pyridazine-3-carbonitrile (commercially available),ES-MS m/e: 551.3 (M+H+). General Procedure II: Aromatic Nucleophilic SubstitutionTo a stirred solution of an amine of type VIII (1 mmol) in DMF (5 mL) was added EtNiPr2 (1.5 mmol) and a substituted chloropyridine, chloropyrimidine, or chloropyridazine (1.3 mmol). The reaction mixture was heated at 60 until completion (reaction monitored by TLC or LCMS). Thereaction mixture was concentrated under vacuo, taken up in EtOAc and washed with H2O several times. The organic phase was dried over Na2SO4, concentrated under vacuo and then purified by preparative HPLC or column chromatography to yield the title product., 35857-89-7
As the paragraph descriping shows that 35857-89-7 is playing an increasingly important role.
Reference£º
Patent; Jablonski, Philippe; Knust, Henner; Nettekoven, Matthias; Patiny-Adam, Angelique; Ratni, Hasane; Riemer, Claus; US2011/53948; (2011); A1;,
Pyridazine – Wikipedia
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