141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate D (1 eq.), silver nitrate (1 eq.), and the appropriate carboxylic acid (1 eq.) were dissolved in water. The reaction mixture was heated to 50C and concentrated sulfuric acid (3eq.) was added. The reaction mixture was heated to 60C and aqueous ammonium per sulphate (3eq.) was added. The reaction mixture was kept at 70C for 30 minutes before cooling to room temperature. pH was adjusted to 8 with 1 N NaOH. The mixture was extracted with ethyl acetate, dried over MgS04, filtered and evaporated. The residue was purified by chromatography on silica gel to provide the desired mono or di substituted 3,6- dichloro-[1 ,2,4]triazolo[4,3-b]pyridazine.Reaction of intermediate D with propionic acid gave a mixture of compounds. Purification on silica gel yielded 6% of 3,6-dichloro-7,8-diethyl-[1 ,2,4]triazolo[4,3-b]pyridazine and 5% of 3,6-dichloro-8-ethyl-[1 ,2,4]triazolo[4,3-b]pyridazine. These intermediates were used to prepare Cpd.5-12 and Cpd.5-13 respectively.Intermediate of Cpd.5-8 was obtained in the same manner with 15% yield.This protocol was also used to prepare intermediate of Cpd.5-14, Cpd.5-1 1 from 3,6- dichloropyridazine with appropriate carboxylic acid with 42% and 81 % yields respectively.
141-30-0, The synthetic route of 141-30-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GENFIT; BOUROTTE, Maryline; DELHOMEL, Jean-Francois; DUBERNET, Mathieu; GOUY, Marie-Helene; WO2013/45519; (2013); A1;,
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