With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20074-67-3,Perchloropyridazine,as a common compound, the synthetic route is as follows.,20074-67-3
1.69 g (10.10 mmol) of carbazole was added to a 250 ml three-necked flask, Then, 100 mL of N,N-dimethylformamide was added as a reaction solvent, Stirred for 10 min on a magnetic stirrer. Under ice-cooling, 0.49 g (20.19 mmol) of NaH was added portionwise to the reaction flask and stirring was continued for 1 h. 0.50 g (2.30 mmol) of 3,4,5,6-tetrachloropyridazine was dissolved in 20 ml of N,N-dimethylformamide was added dropwise to the reaction system. After completion of the addition, the reaction was carried out at 60 C for 15 hours under nitrogen atmosphere. After the reaction, The reaction solution was poured into 150 ml of dilute hydrochloric acid at a concentration of 10% Decompression pumping, washing, drying, The crude product was treated with petroleum ether and ethyl acetate (PE:EA=10:1) The mobile phase was subjected to column chromatography to remove impurities, and then pure methylene chloride (DCM) The column was evaporated to give 1.16 g of a pale yellow solid in 68.0% yield.
As the paragraph descriping shows that 20074-67-3 is playing an increasingly important role.
Reference£º
Patent; Dalian University of Technology; LI, JIUYAN; SUI, KAI; LIU, DI; (19 pag.)CN106243091; (2016); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem