19064-64-3, 3,6-Dichloro-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 3,6-dichloro-4-methylpyridazine (5 g, 30.7 mmol) and concentrated NH40H solution (100 ml) was heated to 120 in a sealed autoclave for 18 hrs at 6 bar. The mixture was cooled to r.t, diluted with water (200 ml) and stirred in an ice bath for 2 hrs. The solid was collected by filtration, washed with water and dried. The filtrate was extracted with CH2Cl2/MeOH (9: 1). The organic was washed with brine, dried over MgSC^, filtered and evaporated. The precipitate from the reaction mixture and the solid isolated by extraction were combined. This crude product was purified by column chromatography using a CH2Cl2/MeOH gradient as eluent, to provide 6-chloro-4-methylpyridazin-3-amine (456 mg, 10%) and 6-chloro-5-methylpyridazin- 3-amine (350 mg, 8%>), both as off-white solids. MS: M = 144.1 (M+H)+ (both isomers)
19064-64-3, 19064-64-3 3,6-Dichloro-4-methylpyridazine 87923, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; LERNER, Christian; WO2014/72261; (2014); A1;,
Pyridazine – Wikipedia
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