141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5L, 3-neck flask was charged with 500.Og (3.356 moles) of 2,6-dichloropyridazine, followed by 1000 mL of methanol. The resulting pale yellow solution was treated with 2300 mL of a 25% (by weight) solution OfNaOCH3 in methanol over 3 hr. The resulting mixture was heated at gentle reflux for 20 hr. Afterward, the mixture was cooled to 4O0C and poured into 6000 mL water/2000 mL CH2Cl2. The aqueous layer was extracted with CH2Cl2 (2×1 L). The combined organics were then dried over MgSO4 to give a white crystalline solid. The solid was further dried in vacuo to give the title compound (458.3g ;97.5% yield). NMR spectrum (DMSO) delta ppm 3.94 (s, 6H) 7.17 (s,2H).
141-30-0, 141-30-0 3,6-Dichloropyridazine 67331, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; ASTRAZENECA AB; ALHAMBRA, Cristobal; CHANG, Hui-Fang (Amy); CHAPDELAINE, Marc; HERZOG, Keith, John; SCHMIESING, Richard, J; WO2011/21979; (2011); A1;,
Pyridazine – Wikipedia
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