With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-67-6,6-Chloro-3-hydroxypyridazine,as a common compound, the synthetic route is as follows.
General procedure: Method A. A mixture of corresponding chloronitropyridine (Ia-c) (1.59 g, 10 mmol), diazole or 3-chloropyridazin-6-one (10 mmol), and powdered K2CO3 (4.14 g) was thoroughly stirred for several hours at a temperature from 45 to 65 C (the exact time and temperature values are shown for the individual compound). The mixture was then cooled, poured into 100 mL of H2O, and the formed precipitate was filtered off and washed with water.
19064-67-6, 19064-67-6 6-Chloro-3-hydroxypyridazine 252828, apyridazine compound, is more and more widely used in various fields.
Reference£º
Article; Klimenko; Divaeva; Zubenko; Morkovnik; Fetisov; Bodryakov; Russian Journal of Bioorganic Chemistry; vol. 41; 4; (2015); p. 402 – 408; Bioorg. Khim.; vol. 41; 4; (2015); p. 454 – 461,8;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem