With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.
To 5-chloro-N2-(3-methylimidazo[1,2-c]pyrimidin-7-yl)-N4-(piperidin-4-yl)pyrimidine-2,4-diamine (30.4 mg, 0.085mmol)And Et3N (135.2 mg, 1.34 mmol)In EtOH (10mL) solution6-chloropyridazine-3-carbonitrile (24.2 mg, 0.173 mmol).The reaction system was stirred at room temperature overnight.After completion of the reaction, the reaction was quenched with water (30 mL)The combined organic layers were washed with brine (50 mL)Filter and concentrate under reduced pressure.The residue obtained is purified by silica gel column chromatography (MeOH/DCM (v/v) = 1 / 20).The title compound was obtained as a beige solid (27.7 mg, yield 70.8%)., 35857-89-7
The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
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