1591827-16-5, Methyl 6-chloro-3-methoxypyridazine-4-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of methyl 6-chloro-3-methoxypyridazine-4-carboxylate (2.0 g, 0.01 mol) in 20 mL of THF was added MeMgBr (7.4 ml, 0.022 mol) at -30 C under a nitrogen atmosphere. The resulting mixture was stirred at 0 C for 1 hr. After finished, the mixture was poured into water and acidified with sat. aq. NH4C1, extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 5: 1) to afford 2-(6-chloro-3-methoxypyridazin-4-yl)propan-2-ol (550 mg). MS (ESI): m/z 203, 205 (M+H)+., 1591827-16-5
The synthetic route of 1591827-16-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; ARRINGTON, Kenneth, L.; BURGEY, Christopher; GILFILLAN, Robert; HAN, Yongxin; PATEL, Mehul; LI, Chun Sing; LI, Yaozong; LUO, Yunfu; LEI, Zhiyu; XU, Jiayi; WO2014/58747; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem