Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38956-79-5,3-Hydrazinyl-6-methylpyridazine,as a common compound, the synthetic route is as follows.

38956-79-5, General procedure: A mixture of corresponding hydrazinylpyridazine 1 or 5 (1 mmol) and aldehyde 2 (1.1 mmol) in ethanol (5 mL) was heated at 60 C for 0.5 h. The formation of hydrazone was checked by TLC and the reaction mixture was cooled to rt. Oxone (1.5 mmol) was added to the mixture at rt followed by tetramethyl ammonium bromide (0.2 mmol) and the resulting mixture was heated at 60 C for another 5 h. The mixture was cooled to rt and extracted with dichloromethane (2 ¡Á 25 mL), dried over anhydrous sodium sulfate and concentrated to obtain a residue which was purified by column chromatography using hexane/ethyl acetate as eluent to furnish the desired triazolopyridazines 4 and 7 (See reference no; 7 for supporting information).

The synthetic route of 38956-79-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ruso, Jayaraman Sembian; Rajendiran, Nagappan; Srinivas, Chowdappa; Murthy, Konappa Narasimha; Soumya, Krishnamurthy; Journal of the Korean Chemical Society; vol. 58; 4; (2014); p. 377 – 380;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

17973-86-3, 3,6-Dibromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

277. 8 mg (2.1 mmol) of hydroxyacetic acid tert-butyl ester and 100.9 mg of sodium hydride (55 % in mineral oil) in 15 ml of DMF were stirred at room temperature for 30 min. Then 500 mg (2.1 mmol) of 3,6-dibrompyridazine were added, and the reaction mixture was stirred at 60 C for 2 h. After evaporation to dryness, the residue was stirred with ethyl acetate, the solution filtered, evaporated, and the crude product (450 mg) directly employed in the subsequent step., 17973-86-3

17973-86-3 3,6-Dibromopyridazine 248852, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; sanofi-aventis; EP1939181; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5788-58-9,4,5-Dibromopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

5788-58-9, A solution of 4,5-dibromopyridazin-3(2H)-one (0.30 g, 1.182 mmol), 4-(2-fluoro-6- methoxyphenyl)piperidine (0.272 g, 1.3 mmol), and DIPEA (0.454 ml, 2.6 mmol) in DMA (2.5 ml) was heated to 100C for 16h. The reaction was cooled and diluted with saturated sodium bicarbonate to give a precipitate. The precipitate was filtered and dried to give 4-bromo-5-(4-(2-fluoro-6-methoxyphenyl)piperidin-l-yl)pyridazin- 3(2H)-one. LCMS: Rt = 0.96 min, (M+H)+ = 384. The material was used without purification.

The synthetic route of 5788-58-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

19064-64-3, 3,6-Dichloro-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of compound 3,6-dichloro-4-methylpyridazine (20.0 g, 122.7 mmol) and ammonium hydroxide in water (86.60 g, 245 mmol) was refluxed for about 30 h. The mixture was concentrated and used in the next step without purification

19064-64-3, As the paragraph descriping shows that 19064-64-3 is playing an increasingly important role.

Reference£º
Patent; GlaxoSmithKline LLC; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; (583 pag.)EP2768509; (2017); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5096-73-1, 6-Chloropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5096-73-1

Step 1: To a mixture of compound 7-1 (4.14 g, 26.1 mmol) in DCM (100 mL) was added oxalyl chloride (3.98 g, 31.3 mmol) dropwise. DMF (0.05 mL) was added and the resulting mixture was stirred at room temperature until the compound 7-1 was dissolved. Then MeOH (2 mL) was added dropwise and stirred for another 0.5 hr. After being washed with brine (100 mL), the mixture was dried over anhydrous Na2SC>4 and concentrated to give crude product. The crude product was purified by silica-gel column chromatography (eluting with PE/EA = 4/1) to yield the desired product 7-2 as white solid. LC-MS: m/z = 173.1

As the paragraph descriping shows that 5096-73-1 is playing an increasingly important role.

Reference£º
Patent; BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas; WO2014/28669; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

3-hydrazino-4-carboxy-6-chloro-pyridazine A mixture of 3,6-dichloro-4-carboxy-pyridazine (20 g; 0.103 mole) and 22 ml of 98% hydrazine hydrate in 200 ml of 50% ethanol was refluxed, under stirring, for one hour. After cooling at 5 C., the solid precipitate was collected, washed with 20 ml of anhydrous ethanol. The solid was suspended in 100 ml of water, the mixture was brought to pH 1-2 with 23% HCl, after cooling at 5 C. the solid was filtered, dried under vacuum at 80 C. to give 18.29 g (93.4%) of the title compound, m.p. 198-201 C. Elemental analysis: found: C, 31.64; H, 2.64; N, 29.32; Cl, 18.53; calculated for C5 H5 ClN4 O2: C, 31.84; H, 2.67; N, 29.71; Cl, 18.80., 51149-08-7

The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Farmitalia Carlo Erba S.p.A.; US4331666; (1982); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

93319-65-4,93319-65-4, Pyridazin-3-ylmethanamine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of phenyl (3,5-difluoro-4-{[3-(trifluoromethyl)-1 -{[2-(trimethylsilyl)ethoxy]methyl}- 1 H-pyrrolo[2,3-b]pyridin-4-yl]oxy}phenyl)carbamate (150 mg, 259 muetaetaomicronIota, intermediate 1 ) in DMF (1 .3 mL) was added 1 -(pyridazin-3-yl)methanamine (28.2 mg, 259 muetaetaomicronIota) and this mixture was stirred at 55 C over night. Additional 1 -(pyridazin-3-yl)methanamine (14.1 mg, 129 muetaetaomicronIota) was added and stirred over night at 60C. After cooling to room temperature ethyl acetate and water was added. After separation of the organic phase the aqueous phase was extracted two times with ethyl acetate. The combined organic phases were washed with brine, dried over sodium sulfate, filtered and concentrated to dryness. The resulting residue was purified via a Biotage chromatography system (1 Og snap KP-Sil column, hexane / 0 – 100% ethyl acetate, then ethyl acetate / 0 – 100% methanol) to obtain 190 mg (84 % purity, 103 % yield) of the desired title compound. -NMR (400 MHz, DMSO-d6) delta [ppm]: -0.1 1 – -0.06 (m, 9H), 0.79 – 0.86 (m, 2H), 3.54 – 3.61 (m, 2H), 4.62 (d, 2H), 5.68 (s, 2H), 6.58 (d, 1 H), 7.23 (t, 1 H), 7.37 – 7.45 (m, 2H), 7.64 (dd, 1 H), 7.70 (dd, 1 H), 8.28 (d, 1 H), 8.36 (s, 1 H), 9.15 (dd, 1 H), 9.43 (s, 1 H).

93319-65-4 Pyridazin-3-ylmethanamine 22639518, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG; BAYER AKTIENGESELLSCHAFT; BUCHMANN, Bernd; SCHMEES, Norbert; MOWAT, Jeffrey Stuart; LEDER, Gabriele; PANKNIN, Olaf; CARRETERO, Rafael; AIGUABELLA FONT, Nuria; BRIEM, Hans; FRIBERG, Anders Roland; HUSEMANN, Manfred; BOeMER, Ulf; STOeCKIGT, Detlef; NEUHAUS, Roland; BERNDT, Sandra; PETERSEN, Kirstin; OFFRINGA, Rienk; (494 pag.)WO2018/228920; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

19064-67-6, 6-Chloro-3-hydroxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 6-chloropyridazin-3(2H)-one (0.200 g, 1.53 mmol), (3-cyano- 5-methoxyphenyl)boronic acid (0.298 g, 1.69 mmol), Cu(OAc)2 (0.0557 g, 0.306 mmol) and pyridine (0.273 mL, 3.37 mmol) in DCM (9.58 mL) was stirred overnight at ambient temperature. The mixture was then diluted with DCM and extracted with water and brine, then dried over anhydrous Na2SO4(), filtered and concentrated under vacuum. The resulting crude residue was purified by silica chromatography to afford the title compound (197 mg, 49% yield). ?H NIVIR (CDC13) 7.60 (t, 1H), 7.49 (t, 1H), 7.28 (d, 1H), 7.18 (m, 1H), 7.40(d, 1H), 3.88 (s, 3H)., 19064-67-6

As the paragraph descriping shows that 19064-67-6 is playing an increasingly important role.

Reference£º
Patent; ARRAY BIOPHARMA, INC.; ANDREWS, Steven W.; BLAKE, James F.; COOK, Adam; GUNAWARDANA, Indrani W.; HUNT, Kevin W.; METCALF, Andrew T.; MORENO, David; REN, Li; TANG, Tony P.; (263 pag.)WO2017/70708; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

A mixture of of 3 ,4,5-trichloropyridazine (0.276 g, 1.506 mmol), 4-(3 -fluorophenyl)piperidine (0.27 g, 1.506 mmol), and potassium carbonate (0.437 g, 3.16 mmol) in dioxane (10 ml) was heated to reflux for 1 h. The mixture was cooled and 35% hydrazine (2.73 ml, 30.1 mmol) was added. The mixture was heated to reflux for an additional 16 h.The reaction was diluted with ethyl acetate and water. The ethyl acetate layer waswashed with water, dried over magnesium sulfate, and concentrated to give 4-chloro-5-(4-(3 -fluorophenyl)piperidin- 1 -yl)-3 -hydrazinylpyridazine (0.25 g, 52%). LCMS:Rt = 1.940 mm, 26%, (M-H) = 320, (M+H) = 322., 14161-11-6

As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,141-30-0

Example 2. 6-4-f4- (5-Chloro-lH-indole-2-sulphonyl)-piperazine-l-carbonvl]-phenyl}-2- (2-dimethylamino-ethvl)-2H-pyridazin-3-one Step A. To a microwave vial was added 3,6-dichloropyridazine (645mg, 4.33mmol), potassium acetate (425 mg, 4.33 mmol) and 9 mL acetic acid/water (5: 1). The reaction mixture was heated at 140 C for 70 minutes. The solvent was evaporated and the crude was purified by preparative HPLC using a gradient of acetonitrile/5 % acetonitrile- water phase containing 0.1 M ammonium acetate, to give 436 mg of 6-chloro-2H- pyridazin-3-one (77 % yield). 1H NMR (400 MHz ; methanol-d4 as solvent and internal reference) delta (ppm) 6.96 (d, 1H), 7.45 (d, 1H).

As the paragraph descriping shows that 141-30-0 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; WO2005/65688; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem