Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932-22-9,4,5-Dichloro-3(2H)-pyridazinone,as a common compound, the synthetic route is as follows.

4,5-dichloropyridazin-3-one (20.06 g, 122.3 mmol)And POCl3 (117 mL, 1280 mmol)The mixture was stirred at reflux for 3 hours.After the reaction,The mixture was cooled to room temperature.A mixed suspension of water and ice (100 mL) was then added.The resulting mixture was adjusted to pH = 10 with saturated aqueous Na 2CO 3.It was then extracted with EtOAc (250 mL x 3).The combined organic layers were washed with brine brine (250 mL)Filter and concentrate under reduced pressure.The residue was purified by silica gel column chromatography (EtOAc /EtOAcThe title compound was obtained as a white solid (17.80 g, yield: 79.3%)., 932-22-9

The synthetic route of 932-22-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Hydrazine hydrate (0.25 mol, 2.5 equiv) was added dropwise to a solution of 4,6 dichloro pyrimidine 3,6 dichloro pyridazine (0.1 mol, 1 equiv) in ethanol (100 mL) for 30 C at room temperature. After stirring at 30 C for 1 h, the reaction mixture after 1 h produced a creamy precipitate. After filtering the product (78% yield), it was used for the next step in the synthesis.

141-30-0, As the paragraph descriping shows that 141-30-0 is playing an increasingly important role.

Reference£º
Article; Rajput, Jamatsing D.; Bagul, Suresh D.; Bendre, Ratnamala S.; Research on Chemical Intermediates; vol. 43; 11; (2017); p. 6601 – 6616;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

289-80-5, Pyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Pyridazine (1.0 eq.) and an alkyl halide (1.1 eq.) were added totoluene (15 mL) and placed in a closed vessel and exposed to irradiation for 5 h at 70 C in a sonicator until a precipitate was formed. The obtained solid was filtered and washed with ethyl acetate to afford the desired pyridazinium IL, 289-80-5

Big data shows that 289-80-5 is playing an increasingly important role.

Reference£º
Article; Messali, Mouslim; Almtiri, Mohammed N.; Abderrahman, Bousskri; Salghi, Rachid; Aouad, Mohamed R.; Alshahateet, Solhe F.; Ali, Adeeb A-S.; South African Journal of Chemistry; vol. 68; (2015); p. 219 – 225;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

Example 39E; Synthesis of 2-(i-butyl)-4-chloro-5-[(4-(l,3-dioxolan-2-yl)phenyl)methoxy]-2- hydropyridazin-3-one (Compound 21); To a vessel charged with (4-(l,3-dioxolan-2-yl)phenyl)methanol (20 g, 110 mmol), benzyltriethylammonium chloride (2.27 g, 10 mmol), toluene (100 mL) and sodium hydroxide (50% in water, 22 mL, 420 mmol) was added a solution of 2-(?-butyl)- 4,5-dichloro-2-hydropyridazin-3-one (22.1 g, 100 mmol) in toluene (100 mL) over 5 min. A gradual and accelerating exotherm occurred with the final internal temperature reaching 39 C. After 2.5 h stirring was halted and MTBE (50 mL) and water (100 mL) added. The phases were split and the organic layer was washed with water (100 mL) and brine (100 mL). The organic extracts were dried (MgS04), filtered, and concentrated under vacuum to afford a tan solid (39 g). The solids were slurried in toluene/heptane (430 mL, 1 : 1) at 40 C for 2 h, cooled to ambient temperature, filtered and dried under vacuum at 40 C for 24 h (29.7 g, 69%).

The synthetic route of 84956-71-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LANTHEUS MEDICAL IMAGING, INC.; CESATI, Richard, R.; CHEESMAN, Edward, H.; LAZEWATSKY, Joel; RADEKE, Heike, S.; CASTNER, James, F.; MONGEAU, Enrico; ZDANKIEWICZ, Dianne, D.; SIEGLER, Robert, Wilburn; DEVINE, Marybeth; WO2011/97649; (2011); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1837-55-4, 3,5-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of tert-butyl 5-(5-chlororyridazin-3-yl)thiorhene-2-carboxylateA solution of 3,5-dichloropyridazine (2.00 g, 13.4 mmol) and tert-butyl 5-(tributylstannyl)thiophene-2-carboxylate (6.35 g, 13.4 mmol, synthesis see above) in 1,4-dioxane (25 mL) was degassed with Ar. CsF(6.12 g, 40.3 mmol), CuCl (0.133 g, 1.34 mmol) and PdCl2(dppf) (0.491 g, 0.671 mmol) were added andthe mixture was heated at7O C for2 h. KF (3.12 g, 53.7 mmol) in 50 mL water was added and themixture was stirred at RT for 2 h. The mixture was filtered over Celite and rinsed with DCM (15 mL) and brine (15 mL). The organic layer was dried over Na2SC4, filtered and concentrated in vacuo. FC (EtOAc/ DCM 0:1 – 1:1) afforded tert-butyl 5-(5-chloropyridazin-3-yl)thiophene-2-carboxylate (2.14 g, 6.65 mmol, 49%). LCMS: calc. for [M+H] = 297.04, found 297.0.

1837-55-4, The synthetic route of 1837-55-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GRUeNENTHAL GMBH; NARDI, Antonio; RATCLIFFE, Paul; CRAAN, Tobias; HERTRAMPF, Thorsten; LESCH, Bernhard; KIME, Robert; STEINHAGEN, Henning; WO2015/161928; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1211591-88-6,5-(Trifluoromethyl)pyridazin-3-amine,as a common compound, the synthetic route is as follows.

To a solution of 2-[6-(2-bromoacetyl)-5-ethylsulfonyl-3-pyridyl]-2-methyl-propanenitrile (300 mg, 0.84mmol, 1.00 equiv.) [compound 12 prepared as described in step 2, example P1] in acetonitrile (6.3 mL)were added 5-(trifluoromethyl)pyridazine-3-amine (150 mg, 0.88 mmol, 1.00 equiv.) [prepared asdescribed in W02016/051193) and magnesium oxide (67 mg, 1.70 mmol, 2.00 equiv.) at roomtemperature under argon atmosphere. The resulting mixture was heated to 90 C overnight. The reaction mixture was cooled down at room temperature, filtered and concentrated. The crude material was diluted with ethyl acetate and satuared ammonium chloride solution. The aqueous layer was separated and extracted twice with ethyl acetate. The organic layers were combined, dried overanhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The crude product was purified by flash chromatography over silica gel (ethyl acetate in cyclohexane) to obtain the title compound. LCMS (method 4): 424 (M+H) retention time: 0.97 mm., 1211591-88-6

The synthetic route of 1211591-88-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; RENDLER, Sebastian; EDMUNDS, Andrew; MUEHLEBACH, Michel; EMERY, Daniel; RAWAL, Girish; SEN, Indira; SIKERVAR, Vikas; (105 pag.)WO2019/53182; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.

tert- butyl bis(4-hydroxybutyl)carbamate(0.39 g)Was dissolved in N, N-dimethylformamide (4.5 mL). Sodium hydride (0.16 g) was added thereto,Then 6-chloropyridazine-3-carbonitrile(0.46 g) was added. This was stirred at room temperature for 22 hours. A saturated aqueous solution of ammonium chloride was added thereto, and then extracted with ethyl acetate. The organic layer was concentrated. The obtained residue was purified by silica gel column chromatography to give the title compound (0.24 g). The NMR analysis result of the obtained compound was as follows.

35857-89-7, The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NIPPON SODA COMPANY LIMITED; IHORI, YOICHI; SHIBAYAMA, KOTARO; INOUE, SHUJI; KANG, CHANG-KYUNG; SHIINOKI, YASUYUKI; NISHIMURA, SATOSHI; (60 pag.)JP2016/222655; (2016); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

Potassium dichromate (3.3 g, 11.2 mmol) was added in portions to a solution of 3-Chloro-6-methyl-pyridazine (1.2 g, 9.3 mmol) in [H2SO4] (10 ml). After addition the mixture is stirred at 50 [C] on. The reaction was pored on ice and the mixture was extracted three times with diethyl ether. The combined organic phases were dried and concentrated to give the title compound (840 mg, 57%). [LC-MS] [(M++1)] : 159 and 161 (3: 1).

1121-79-5, As the paragraph descriping shows that 1121-79-5 is playing an increasingly important role.

Reference£º
Patent; ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14881; (2004); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

XVII.1.a3,6-Diiodo-pyridazine; 14.9 g (0.1 mol) 3,6-Dichloro-pyridazine and 120 ml (0.54 mol) hydroiodic acid are refluxed for 0.5 hours at 150C. After that time the mixture is cooled down and poured into 0.4 N NaOH solution/ice water. The precipitate is filtered off, taken up in methylene chloride and dried over sodium sulphate. After evaporation of the solvent, the product is dried in vacuo at50CYield: 28.3 g (85% of theory),C4H2I2N2 EII Mass spectrum: m/z = 333 [M+H]+M. p. 165-168 C, 141-30-0

As the paragraph descriping shows that 141-30-0 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2007/48802; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4603-59-2,3,6-Dimethoxypyridazine,as a common compound, the synthetic route is as follows.

4-Chloro-3,6-dimethoxy-pyridazine: A solution of n-butyllithium (1.6 M in hexanes, 2.45 mL, 3.92 mmol) was added to a cold solution of THF (20 mL) at -78 C. Tetramethylpiperidine (0.67 mL, 3.92 mol) was introduced and the solution was warmed to 0 C. and kept at this temperature for 20 min; it was then cooled to -78 C. A solution of 3,6-dimethoxy-pyridazine (500 mg, 3.57 mmol) in THF (5 mL) was added slowly and the mixture was stirred at -78 C. for 45 min. This reaction mixture was transferred to a solution of achloroethane (1.268 g, 5.36 mmol) in THF (10 mL) at -78 C. and stirring was continued at -78 C. for 15 min. Saturated aqueous NH4Cl was added and the mixture was warmed to room temperature. The mixture was extracted with EtOAc, dried over MgSO4, and concentrated in vacuo to give the crude product, which was purified by flash chromatography, eluding with 10-20% EtOAc in hexanes to afford, after evaporation, the title compound as a white solid (372 mg, 60%): 1H NMR (400 MHz, DMSO) delta 7.04 (s, 1H), 4.11 (s, 3H), 4.04 (s, 3H); LCMS (+ESI, M+H+) m/z 175., 4603-59-2

The synthetic route of 4603-59-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beaulieu, Francis; Marinier, Anne; Ouellet, Carl; Roy, Stephan; Wittman, Mark D.; US2005/54655; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem