1837-55-4, 3,5-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Synthesis of tert-butyl 5-(5-chlororyridazin-3-yl)thiorhene-2-carboxylateA solution of 3,5-dichloropyridazine (2.00 g, 13.4 mmol) and tert-butyl 5-(tributylstannyl)thiophene-2-carboxylate (6.35 g, 13.4 mmol, synthesis see above) in 1,4-dioxane (25 mL) was degassed with Ar. CsF(6.12 g, 40.3 mmol), CuCl (0.133 g, 1.34 mmol) and PdCl2(dppf) (0.491 g, 0.671 mmol) were added andthe mixture was heated at7O C for2 h. KF (3.12 g, 53.7 mmol) in 50 mL water was added and themixture was stirred at RT for 2 h. The mixture was filtered over Celite and rinsed with DCM (15 mL) and brine (15 mL). The organic layer was dried over Na2SC4, filtered and concentrated in vacuo. FC (EtOAc/ DCM 0:1 – 1:1) afforded tert-butyl 5-(5-chloropyridazin-3-yl)thiophene-2-carboxylate (2.14 g, 6.65 mmol, 49%). LCMS: calc. for [M+H] = 297.04, found 297.0.
1837-55-4, The synthetic route of 1837-55-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GRUeNENTHAL GMBH; NARDI, Antonio; RATCLIFFE, Paul; CRAAN, Tobias; HERTRAMPF, Thorsten; LESCH, Bernhard; KIME, Robert; STEINHAGEN, Henning; WO2015/161928; (2015); A1;,
Pyridazine – Wikipedia
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