84956-71-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
Example 39E; Synthesis of 2-(i-butyl)-4-chloro-5-[(4-(l,3-dioxolan-2-yl)phenyl)methoxy]-2- hydropyridazin-3-one (Compound 21); To a vessel charged with (4-(l,3-dioxolan-2-yl)phenyl)methanol (20 g, 110 mmol), benzyltriethylammonium chloride (2.27 g, 10 mmol), toluene (100 mL) and sodium hydroxide (50% in water, 22 mL, 420 mmol) was added a solution of 2-(?-butyl)- 4,5-dichloro-2-hydropyridazin-3-one (22.1 g, 100 mmol) in toluene (100 mL) over 5 min. A gradual and accelerating exotherm occurred with the final internal temperature reaching 39 C. After 2.5 h stirring was halted and MTBE (50 mL) and water (100 mL) added. The phases were split and the organic layer was washed with water (100 mL) and brine (100 mL). The organic extracts were dried (MgS04), filtered, and concentrated under vacuum to afford a tan solid (39 g). The solids were slurried in toluene/heptane (430 mL, 1 : 1) at 40 C for 2 h, cooled to ambient temperature, filtered and dried under vacuum at 40 C for 24 h (29.7 g, 69%).
The synthetic route of 84956-71-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; LANTHEUS MEDICAL IMAGING, INC.; CESATI, Richard, R.; CHEESMAN, Edward, H.; LAZEWATSKY, Joel; RADEKE, Heike, S.; CASTNER, James, F.; MONGEAU, Enrico; ZDANKIEWICZ, Dianne, D.; SIEGLER, Robert, Wilburn; DEVINE, Marybeth; WO2011/97649; (2011); A2;,
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