With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.
tert- butyl bis(4-hydroxybutyl)carbamate(0.39 g)Was dissolved in N, N-dimethylformamide (4.5 mL). Sodium hydride (0.16 g) was added thereto,Then 6-chloropyridazine-3-carbonitrile(0.46 g) was added. This was stirred at room temperature for 22 hours. A saturated aqueous solution of ammonium chloride was added thereto, and then extracted with ethyl acetate. The organic layer was concentrated. The obtained residue was purified by silica gel column chromatography to give the title compound (0.24 g). The NMR analysis result of the obtained compound was as follows.
35857-89-7, The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NIPPON SODA COMPANY LIMITED; IHORI, YOICHI; SHIBAYAMA, KOTARO; INOUE, SHUJI; KANG, CHANG-KYUNG; SHIINOKI, YASUYUKI; NISHIMURA, SATOSHI; (60 pag.)JP2016/222655; (2016); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem