492431-11-5, 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation of 6-(Piperazin-1-yl)pyridazin-3(2H)-one 6-4: (1204) A solution of tert-butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate 6-3 (2.2 g, 7.36 mmol) in acetic acid (20mL) was heated at 120 C for 16 h. After complete consumption of Cpd-3 as evident from TLC, the volatiles were stripped off, residue partitioned between ethyl acetate and water, combined organic extracts evaporated to afford a crude residue which was purified over neutral alumina (elution with 30% methanol/DCM)to afford 6-(piperazin-1- yl)pyridazin-3(2H)-one 6-4 (871 mg, 4.83 mmol, 65.9 %) as a brown solid. LC MS: ES+ 181.1
492431-11-5, The synthetic route of 492431-11-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; CHEN, Chi-li; DUPLESSIS, Martin; HE, Minsheng; LAZARSKI, Kiel; (980 pag.)WO2017/197051; (2017); A1;,
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