With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
51149-08-7, Production Example 16 (1) [0971] A mixture of 693 mg of N2-methyl-5-trifluoromethylpyridine-2,3-diamine, 700 mg of 3,6-dichloropyridazine-carboxylic acid, 1.04 g of EDCI hydrochloride, 50 mg of HOBt and 2.5 ml of pyridine was stirred at room temperature for 4 hours and then allowed to stand at room temperature overnight. Water was poured to the reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 1.19 g of 3, 6-dichloropyridazine-4-carboxylic acid (2-methylamlno-5-trifluoromethylpyridin-3-yl)-amide. 3,6-Dichloropyridazine-4-carboxylic acid (2-methylamino-5-trifluoromethylpyridin-3-yl)-amide 1H-NMR (CDCl3) delta: 8.44 (1H, s), 8.01(1H, s), 7.78 (1H, s), 4.99(1H, brs), 3.10(3H, d).
The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sumitomo Chemical Company Limited; TAKAHASHI, Masaki; ITO, Mai; NOKURA, Yoshihiko; TANABE, Takamasa; SHIMIZU, Chie; EP2857397; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem