With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34584-69-5,3,6-Dichloro-4,5-dimethylpyridazine,as a common compound, the synthetic route is as follows.
A suspension of 3,6-dichloro-4,5-dimethyl-pyridazine (3.0 g, 17 mmol) in aqueous NaOH (3.3 N, 28 mL) is stirred at reflux for 2 h. The reaction is cooled to room temperature and acetic acid (50percent solution in water, 19 mL) is added. The formed precipitate is extracted with 9: 1 ethyl acetate :THF (3 x 100 mL). The combined organic extracts are dried over Na2S04 and concentrated under reduced pressure to afford the desired compound. (1292) [0343] LCMS: MW (calcd): 159; m/z MW (obsd): 160 (M+H). 1.66
34584-69-5, As the paragraph descriping shows that 34584-69-5 is playing an increasingly important role.
Reference£º
Patent; GALAPAGOS NV; MAMMOLITI, Oscar; JANSEN, Koen, Karel; PALISSE, Adeline, Marie, Elise; JOANNESSE, Caroline, Martine, Andree-Marie; MENET, Christel, Jeanne, Marie; ALLART, Brigitte; EL BKASSINY, Sandy; (186 pag.)WO2017/148787; (2017); A1;,
Pyridazine – Wikipedia
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