With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5788-58-9,4,5-Dibromopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
5788-58-9, A solution of 4,5-dibromopyridazin-3(2H)-one (0.30 g, 1.182 mmol), 4-(2-fluoro-6- methoxyphenyl)piperidine (0.272 g, 1.3 mmol), and DIPEA (0.454 ml, 2.6 mmol) in DMA (2.5 ml) was heated to 100C for 16h. The reaction was cooled and diluted with saturated sodium bicarbonate to give a precipitate. The precipitate was filtered and dried to give 4-bromo-5-(4-(2-fluoro-6-methoxyphenyl)piperidin-l-yl)pyridazin- 3(2H)-one. LCMS: Rt = 0.96 min, (M+H)+ = 384. The material was used without purification.
The synthetic route of 5788-58-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
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