With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.
A mixture of of 3 ,4,5-trichloropyridazine (0.276 g, 1.506 mmol), 4-(3 -fluorophenyl)piperidine (0.27 g, 1.506 mmol), and potassium carbonate (0.437 g, 3.16 mmol) in dioxane (10 ml) was heated to reflux for 1 h. The mixture was cooled and 35% hydrazine (2.73 ml, 30.1 mmol) was added. The mixture was heated to reflux for an additional 16 h.The reaction was diluted with ethyl acetate and water. The ethyl acetate layer waswashed with water, dried over magnesium sulfate, and concentrated to give 4-chloro-5-(4-(3 -fluorophenyl)piperidin- 1 -yl)-3 -hydrazinylpyridazine (0.25 g, 52%). LCMS:Rt = 1.940 mm, 26%, (M-H) = 320, (M+H) = 322., 14161-11-6
As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
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