33471-40-8, 4-Methylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The product of step c) (12.2 g, 0.112 mol) in phosphorus oxychloride (125 ML) was heated at 90C for 3 h. The mixture was cooled to room temperature and concentrated almost to dryness. The residue was poured into ice/water, made basic by careful addition of 4N NAOH and extracted with ether. The aqueous phase was re-extracted with DCM. The organic phases were combined, washed with water, dried over sodium sulphate, filtered and concentrated to dryness. The residue was purified by flash chromatography on silica gel in 2: 1 ethyl acetate- isohexane to give an orange solid (11.2 g, 78%). LH NMR (400 MHz, CDCIs) 8 8.97 (1 H, d, J = 4. 9 HZ), 7.35 (1 H, d, J = 4. 9 HZ), 2.44 (3 H, s) ppm., 33471-40-8
33471-40-8 4-Methylpyridazin-3(2H)-one 11412358, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2004/74290; (2004); A1;,
Pyridazine – Wikipedia
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