15456-86-7, 4-Bromo-1,2-dihydropyridazine-3,6-dione is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Essentially as previously described (/. Neuroinflamm. 2007, 4, 21 ; herein incorporated by reference in its entirety), compound 1-1 (2 g, 10.4 mmol, 1 eq) and pyridin-4-yI boronic acid (14,3 mmol, 1.76 g, 1.37 eq) were suspended in dimeihoxyeihane and water (10: 1 v/v) in a heavy wall pressure vessel and purged with argon for 15 min. Tetrakis(triphenylphosphine)palladium (0.1 eq) and sodium carbonate (3eq) were added, the vessel immediately capped, the reaction mixture heated (1 10 C ) for 18 h, then cooled to ambient temperature and subjected to filtration on a medium frit sintered glass funnel containing Ceiite 545. The filtrate was concentrated in vacuo and the concentrate triturated with hexane. The yellow product 1 -2 (2.2 g) exhibited a mass (ESI) of m/z (MeOH) =190.06 (MET), and was taken to the next step without further purification., 15456-86-7
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Reference£º
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; ARANCIO, Ottavio; WATTERSON, Daniel, Martin; PELLETIER, Jeffrey, Claude; ROY, Saktimayee, Mitra; WO2014/145485; (2014); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem