With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.
To 4-yl amino-carboxylate (1.40g, 6.99mmol) and 6-chloro-pyridazin-3-carbonitrile (967.4mg, 6.93mmol) in ethanol(20mL) was added triethylamine (976.2mg, 9.65mmol) solution. The reaction was stirred overnight at room temperature, and then concentrated under reduced pressure. IncomeThe residue was mixed solvent of ethanol and water (10mL / 1mL) beating 0.5 hours, filtered to give the title compound as a light brown solid (2.13g,100% yield).
35857-89-7, The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Xi, Ning; Li, Minxiong; Li, Xiaobo; Dai, Weilong; Hu, Haiyang; Zhang, Tao; Chen, Wuhong; (105 pag.)CN105461694; (2016); A;,
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