Some tips on 70952-62-4

70952-62-4, 3,6-Dichloro-4-methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Description 1; 4-(6-Chloro-4-methoxy-pyridazin-3-ylamino)-piperidine-l-carboxylic acid tert- butyl ester (Dl); To a stirred solution of 3,6-dichloro-4-methoxy-pyridazine (0.73 g, 4.08mmol) (prepared by a procedure similar to that described in Eichenberger, K.; Rometsch, R..; Druey, J. Australian Journal of Chemistry 1956, 9, 1755-1764), 4-amino-piperidine-l- carboxylic acid tert-bvXy ester (0.98 g, 4.90 mmol) and cesium carbonate (2.66 g, 8.16 mmol) in toluene (15 ml) in a sealed tube under nitrogen, were added (R)-(+)-2,T- bis(diphenylphosphino)-l,r-binaphthyl (0.38 g, 0.61 mmol) and palladium(II) acetate (0.046 g, 0.20 mmol). The reactiom mixture was stirred at 110 C for 18 h.. After cooling to room temperature, the reaction mixture was filtered though Celite and the filtrate was evaporated. The crude product was purified by flash column chromatography (silica gel; 3 % ammonia in methanol (7M) / dichloromethane). The desired fractions were collected and evaporated in vacuo, to yield Dl (0.44 g, 32 %) as a yellow solid. Ci5H23ClN4O3 requires 342; Found 343 (MH+).

70952-62-4, The synthetic route of 70952-62-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/128995; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem