With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.
A mixture of 3,4,5-trichloropyridazine (0.250 g, 1.363 mmol), 4-(3- methoxyphenyl)piperidine (0.26 1 g, 1.363 mmol), and potassium carbonate (0.3 96 g, 2.86 mmol) in dioxane (10 ml) was heated to reflux for 1 h. The mixture was cooled and 35% hydrazine (2.469 ml, 27.3 mmol) was added. The mixture was heated to reflux for 16 h. The mixture was heated to reflux for an additional 16 h. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give 4-chloro-3-hydrazinyl- 5-(4-(2-methoxyphenyl)piperidin-1-yl)pyridazine as a brown oil oil that was usedwithout purification. LCMS: Rt = 0.77 mm, 22%, (M+H) = 334.
14161-11-6, 14161-11-6 3,4,5-Trichloropyridazine 70111, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem